Is the use of letrozole to induce ovulation teratogenic?

Simerpal Kaur Gill, Myla Moretti, Gideon Koren

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

QUESTION: A patient of mine has been prescribed letrozole to induce ovulation; however, a recent release from the Food and Drug Administration contraindicates the use of letrozole in premenopausal women owing to teratogenicity. Does the use of letrozole increase the risk of a child being born with a birth defect? ANSWER: The use of letrozole to induce ovulation has not been associated with an increased risk of a child being born with a birth defect; in contrast, the use of clomiphene citrate in pregnancy is associated with intrauterine growth restriction.

Original languageEnglish
Pages (from-to)353-354
Number of pages2
JournalCanadian Family Physician
Volume54
Issue number3
StatePublished - Mar 2008
Externally publishedYes

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