Abstract
Studies of the association between vaginal spermicides and adverse fetal outcomes have produced conflicting results. Meta-analysis allows data from different studies to be combined so that appropriate statistical power can be achieved. Nine studies investigating teratogenicity met the inclusion criteria. The Mantel-Haenszel summary odds ratio was 1.02 (95% confidence interval, 0.78-1.32), suggesting that maternal use of spermicides is not associated with fetal malformations or any other adverse fetal outcomes. Meta-analysis is recommended as the standard for evaluating reproductive outcomes after exposure to drugs, chemicals, radiation, and infections during pregnancy.
| Original language | English |
|---|---|
| Pages (from-to) | 431-432 |
| Number of pages | 2 |
| Journal | Canadian Family Physician |
| Volume | 43 |
| State | Published - Mar 1997 |
| Externally published | Yes |