Is post exposure prevention of teratogenic damage possible: Studies on diabetes, valproic acid, alcohol and anti folates in pregnancy: Animal studies with reflection to human

Asher Ornoy, Gideon Koren, Joseph Yanai

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

We discuss the possibilities to prevent the post-exposure teratogenic effects of several teratogens: valproic acid (VPA), diabetes and alcohol. Co-administration of folic acid with VPA reduced the rate of Neural Tube Defects (NTD) and other anomalies in rodents, but apparently not in pregnant women. Antioxidants or the methyl donor S-adenosyl methionine prevented Autism Spectrum Disorder (ASD) like behavior in mice and rats. In vivo and in vitro studies demonstrated that antioxidants, arachidonic acid, myoinositol and nutritional agents may prevent diabetes-embryopathy. Prevention of alcohol–induced embryonic and fetal injuries and neurodevelopmental deficits was achieved by supplementation of zinc, choline, vasoactive intestinal proteins (VIP related peptides), antioxidants and folic acid. While the animal research described in this review is indicative of possible preventions of the different teratogenic effects, this is not yet the focus in human research. Future research should promote further knowledge where our current understanding is the vaguest, human prevention.

Original languageEnglish
Pages (from-to)92-104
Number of pages13
JournalReproductive Toxicology
Volume80
DOIs
StatePublished - Sep 2018
Externally publishedYes

Keywords

  • Alcohol
  • Animals
  • Antioxidants
  • Diabetes
  • Folic acid
  • Human
  • Neurobehavioral effects
  • Post exposure prevention
  • Pregnancy
  • Subteratogenic dose
  • Teratogenicity
  • Valproic acid

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