Is carbamazepine teratogenic? A prospective controlled study of 210 pregnancies

Orna Diav-Citrin; Svetlana Shechtman; Judy Arnon; Asher Ornoy

doi:10.1212/WNL.57.2.321

Is carbamazepine teratogenic? A prospective controlled study of 210 pregnancies

Orna Diav-Citrin, Svetlana Shechtman, Judy Arnon, Asher Ornoy

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

The Israeli Teratogen Information Service prospectively followed up 210 pregnancies with first trimester carbamazepine exposure. Pregnancy outcome was compared with that of two overlapping controls, matched and general (n = 629), exposed to nonteratogenic agents. Our study suggests a twofold increase in the rate of major congenital anomalies (12/160 [carbamazepine] versus 18/560 [general control]; relative risk 2.24; 95% CI 1.1-4.56) and a birth weight reduction of approximately 250 g after in utero exposure to carbamazepine.

Original language	English
Pages (from-to)	321-324
Number of pages	4
Journal	Neurology
Volume	57
Issue number	2
DOIs	https://doi.org/10.1212/WNL.57.2.321
State	Published - 24 Jul 2001
Externally published	Yes

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title = "Is carbamazepine teratogenic? A prospective controlled study of 210 pregnancies",

abstract = "The Israeli Teratogen Information Service prospectively followed up 210 pregnancies with first trimester carbamazepine exposure. Pregnancy outcome was compared with that of two overlapping controls, matched and general (n = 629), exposed to nonteratogenic agents. Our study suggests a twofold increase in the rate of major congenital anomalies (12/160 [carbamazepine] versus 18/560 [general control]; relative risk 2.24; 95\% CI 1.1-4.56) and a birth weight reduction of approximately 250 g after in utero exposure to carbamazepine.",

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AB - The Israeli Teratogen Information Service prospectively followed up 210 pregnancies with first trimester carbamazepine exposure. Pregnancy outcome was compared with that of two overlapping controls, matched and general (n = 629), exposed to nonteratogenic agents. Our study suggests a twofold increase in the rate of major congenital anomalies (12/160 [carbamazepine] versus 18/560 [general control]; relative risk 2.24; 95% CI 1.1-4.56) and a birth weight reduction of approximately 250 g after in utero exposure to carbamazepine.

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Is carbamazepine teratogenic? A prospective controlled study of 210 pregnancies

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