Iodinated xanthene-cyanine NIR dyes as potential photosensitizers for antimicrobial photodynamic therapy

T. M. Ebaston; Faina Nakonechny; Efrosiniia Talalai; Gary Gellerman; Leonid Patsenker

doi:10.1016/j.dyepig.2020.108854

Iodinated xanthene-cyanine NIR dyes as potential photosensitizers for antimicrobial photodynamic therapy

T. M. Ebaston, Faina Nakonechny, Efrosiniia Talalai, Gary Gellerman, Leonid Patsenker

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Photosensitizers (PSs) are chemical entities that upon light exposure are able to produce cytotoxic species such as singlet oxygen superoxide and free radicals. PSs are used in photodynamic therapy applications (PDT) to eradicate cancer cells, pathogenic bacteria, fungi, and viruses. Development of the NIR-activatable photosensitizes with high phototoxicity and low toxicity in dark conditions is challenging. Here we first report on the synthesis and antimicrobial testing of the new NIR photosensitizers based on the iodinated xanthene-cyanine dyes. These new photosensitizers exhibit high antimicrobial efficacy on Staphylococcus aureus pathogens at low dye concentration (~0.5 μM) and low NIR light dose (24.3 J/cm²).

Original language	English
Article number	108854
Journal	Dyes and Pigments
Volume	184
DOIs	https://doi.org/10.1016/j.dyepig.2020.108854
State	Published - Jan 2021

Keywords

APDT
Antimicrobial photodynamic therapy
Iodinated dye
Photosensitizer
Staphylococcus aureus
Xanthene-cyanine dye

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10.1016/j.dyepig.2020.108854

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title = "Iodinated xanthene-cyanine NIR dyes as potential photosensitizers for antimicrobial photodynamic therapy",

abstract = "Photosensitizers (PSs) are chemical entities that upon light exposure are able to produce cytotoxic species such as singlet oxygen superoxide and free radicals. PSs are used in photodynamic therapy applications (PDT) to eradicate cancer cells, pathogenic bacteria, fungi, and viruses. Development of the NIR-activatable photosensitizes with high phototoxicity and low toxicity in dark conditions is challenging. Here we first report on the synthesis and antimicrobial testing of the new NIR photosensitizers based on the iodinated xanthene-cyanine dyes. These new photosensitizers exhibit high antimicrobial efficacy on Staphylococcus aureus pathogens at low dye concentration (~0.5 μM) and low NIR light dose (24.3 J/cm2).",

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AU - Ebaston, T. M.

AU - Nakonechny, Faina

AU - Talalai, Efrosiniia

AU - Gellerman, Gary

AU - Patsenker, Leonid

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AB - Photosensitizers (PSs) are chemical entities that upon light exposure are able to produce cytotoxic species such as singlet oxygen superoxide and free radicals. PSs are used in photodynamic therapy applications (PDT) to eradicate cancer cells, pathogenic bacteria, fungi, and viruses. Development of the NIR-activatable photosensitizes with high phototoxicity and low toxicity in dark conditions is challenging. Here we first report on the synthesis and antimicrobial testing of the new NIR photosensitizers based on the iodinated xanthene-cyanine dyes. These new photosensitizers exhibit high antimicrobial efficacy on Staphylococcus aureus pathogens at low dye concentration (~0.5 μM) and low NIR light dose (24.3 J/cm2).

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Iodinated xanthene-cyanine NIR dyes as potential photosensitizers for antimicrobial photodynamic therapy

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