TY - JOUR
T1 - Involvement of the neuropeptide corticotropin-releasing hormone in an animal model of Shigella-related seizures
AU - Yuhas, Yael
AU - Weizman, Abraham
AU - Chrousos, George P.
AU - Ovadia, Hilla
AU - Ashkenazi, Shai
N1 - Funding Information:
This work was supported by the Wasserman Research Foundation, Tel Aviv University Medical School.
PY - 2004/8
Y1 - 2004/8
N2 - Convulsions are common complications of shigellosis in children. Corticotropin-releasing hormone (CRH), a stress neurohormone, has been implicated in the susceptibility of young children to seizures. We investigated the role of CRH in Shigella-related seizures. Pretreatment with Shigella dysenteriae sonicate enhanced mice response to pentylenetetrazole (PTZ)-induced seizures. Preinjection of antalarmin, a CRH-receptor 1 antagonist, decreased both the mean convulsion score (MCS: 1.6 vs. 1.1, p<0.05) and the percent of mice having seizures (48% vs. 28%, p=0.03). This indicates that CRH plays a role in the increased susceptibility to seizures following exposure to S. dysenteriae.
AB - Convulsions are common complications of shigellosis in children. Corticotropin-releasing hormone (CRH), a stress neurohormone, has been implicated in the susceptibility of young children to seizures. We investigated the role of CRH in Shigella-related seizures. Pretreatment with Shigella dysenteriae sonicate enhanced mice response to pentylenetetrazole (PTZ)-induced seizures. Preinjection of antalarmin, a CRH-receptor 1 antagonist, decreased both the mean convulsion score (MCS: 1.6 vs. 1.1, p<0.05) and the percent of mice having seizures (48% vs. 28%, p=0.03). This indicates that CRH plays a role in the increased susceptibility to seizures following exposure to S. dysenteriae.
KW - Children
KW - Cortricotropin-releasing hormone (CRH)
KW - Seizures
KW - Shigella
UR - http://www.scopus.com/inward/record.url?scp=3242730212&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2004.04.009
DO - 10.1016/j.jneuroim.2004.04.009
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C2 - 15265661
AN - SCOPUS:3242730212
SN - 0165-5728
VL - 153
SP - 36
EP - 39
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -