Involvement of prostaglandins in an animal model of Shigella-related seizures

Yael Yuhas; Abraham Weizman; Alexey Vanichkin; Shai Ashkenazi

doi:10.1016/j.jneuroim.2005.06.029

Involvement of prostaglandins in an animal model of Shigella-related seizures

Yael Yuhas, Abraham Weizman, Alexey Vanichkin, Shai Ashkenazi

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We investigated whether prostaglandins (PGs), proinflammatory mediators implicated in excitatory activity, are involved in Shigella-related seizures. Pretreatment with S. dysenteriae sonicate (2LD₅₀) enhanced mice response to pentylenetetrazole-induced seizures, without increase of brain concentrations of PGE₂, PGD₂ or PGF_2α. Preinjection of NS-398, an inhibitor of cyclooxygenase-2, before treatment with Shigella sonicate, had no effect on seizures. The anticonvulsive PGD₂ increased after injection of 8 LD₅₀ of Shigella sonicate, which did not enhance seizures (32 pg/mg vs 26 pg/ml, p = 0.0063). The findings indicate that PGs are not involved in the enhanced seizure response after exposure to Shigella. However, induction of PGD₂ may play an inhibitory role.

Original language	English
Pages (from-to)	34-39
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	168
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2005.06.029
State	Published - Nov 2005
Externally published	Yes

Keywords

Animal model
Prostaglandins
Seizures
Shigella

Access to Document

10.1016/j.jneuroim.2005.06.029

Cite this

@article{e6fe10c9dafe47b2a16aba705c63ec3b,

title = "Involvement of prostaglandins in an animal model of Shigella-related seizures",

abstract = "We investigated whether prostaglandins (PGs), proinflammatory mediators implicated in excitatory activity, are involved in Shigella-related seizures. Pretreatment with S. dysenteriae sonicate (2LD50) enhanced mice response to pentylenetetrazole-induced seizures, without increase of brain concentrations of PGE2, PGD2 or PGF2α. Preinjection of NS-398, an inhibitor of cyclooxygenase-2, before treatment with Shigella sonicate, had no effect on seizures. The anticonvulsive PGD2 increased after injection of 8 LD50 of Shigella sonicate, which did not enhance seizures (32 pg/mg vs 26 pg/ml, p = 0.0063). The findings indicate that PGs are not involved in the enhanced seizure response after exposure to Shigella. However, induction of PGD2 may play an inhibitory role.",

keywords = "Animal model, Prostaglandins, Seizures, Shigella",

author = "Yael Yuhas and Abraham Weizman and Alexey Vanichkin and Shai Ashkenazi",

year = "2005",

month = nov,

doi = "10.1016/j.jneuroim.2005.06.029",

language = "אנגלית",

volume = "168",

pages = "34--39",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Involvement of prostaglandins in an animal model of Shigella-related seizures

AU - Yuhas, Yael

AU - Weizman, Abraham

AU - Vanichkin, Alexey

AU - Ashkenazi, Shai

PY - 2005/11

Y1 - 2005/11

N2 - We investigated whether prostaglandins (PGs), proinflammatory mediators implicated in excitatory activity, are involved in Shigella-related seizures. Pretreatment with S. dysenteriae sonicate (2LD50) enhanced mice response to pentylenetetrazole-induced seizures, without increase of brain concentrations of PGE2, PGD2 or PGF2α. Preinjection of NS-398, an inhibitor of cyclooxygenase-2, before treatment with Shigella sonicate, had no effect on seizures. The anticonvulsive PGD2 increased after injection of 8 LD50 of Shigella sonicate, which did not enhance seizures (32 pg/mg vs 26 pg/ml, p = 0.0063). The findings indicate that PGs are not involved in the enhanced seizure response after exposure to Shigella. However, induction of PGD2 may play an inhibitory role.

AB - We investigated whether prostaglandins (PGs), proinflammatory mediators implicated in excitatory activity, are involved in Shigella-related seizures. Pretreatment with S. dysenteriae sonicate (2LD50) enhanced mice response to pentylenetetrazole-induced seizures, without increase of brain concentrations of PGE2, PGD2 or PGF2α. Preinjection of NS-398, an inhibitor of cyclooxygenase-2, before treatment with Shigella sonicate, had no effect on seizures. The anticonvulsive PGD2 increased after injection of 8 LD50 of Shigella sonicate, which did not enhance seizures (32 pg/mg vs 26 pg/ml, p = 0.0063). The findings indicate that PGs are not involved in the enhanced seizure response after exposure to Shigella. However, induction of PGD2 may play an inhibitory role.

KW - Animal model

KW - Prostaglandins

KW - Seizures

KW - Shigella

UR - http://www.scopus.com/inward/record.url?scp=25844494539&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2005.06.029

DO - 10.1016/j.jneuroim.2005.06.029

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 16139898

AN - SCOPUS:25844494539

SN - 0165-5728

VL - 168

SP - 34

EP - 39

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Involvement of prostaglandins in an animal model of Shigella-related seizures

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this