TY - JOUR
T1 - Intestinal electrolyte transport and diarrheal disease
AU - Cleary, Thomas G.
AU - Ashkenazi, Shai
AU - Field, Michael
PY - 1990/5/3
Y1 - 1990/5/3
N2 - To the Editor: The review of intestinal electrolyte transport and diarrheal disease by Field et al. (Sept. 28 issue)1 contains a number of statements about the structure, mechanism, and role of Shiga toxin in shigellosis that are incorrect. The molecular weight and mechanism of action have recently been clarified. The molecular weight of Shiga toxin is now known, on the basis of DNA-sequence data, to be 70,675.2,3 Although the toxin was thought for a time to bind to glycoproteins, it is now clear that the receptor is galabiose on the neutral glycolipid globotriaosylceramide.4,5 Shiga toxin does not act on a.
AB - To the Editor: The review of intestinal electrolyte transport and diarrheal disease by Field et al. (Sept. 28 issue)1 contains a number of statements about the structure, mechanism, and role of Shiga toxin in shigellosis that are incorrect. The molecular weight and mechanism of action have recently been clarified. The molecular weight of Shiga toxin is now known, on the basis of DNA-sequence data, to be 70,675.2,3 Although the toxin was thought for a time to bind to glycoproteins, it is now clear that the receptor is galabiose on the neutral glycolipid globotriaosylceramide.4,5 Shiga toxin does not act on a.
UR - http://www.scopus.com/inward/record.url?scp=0025267586&partnerID=8YFLogxK
U2 - 10.1056/NEJM199005033221817
DO - 10.1056/NEJM199005033221817
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C2 - 2325728
AN - SCOPUS:0025267586
SN - 0028-4793
VL - 322
SP - 1321
EP - 1322
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 18
ER -