Interkinetic nuclear movement in the ventricular zone of the cortex

Orly Reiner, Tamar Sapir, Gabi Gerlitz

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


The nuclei of neuroepithelial cells move along the apicobasal axis in synchronization with their cell cycle status. This motility is known as interkinetic nuclear movement. We discuss here the importance of cytoskeleton organization, the centrosome, molecular motors, cell polarity proteins, and their regulators in controlling and maintaining this typical behavior. Furthermore, due to the tight linkage between cell proliferation, cell cycle, and nuclear motility, we speculate that interkinetic nuclear movement is likely to be affected in the pathophysiology of microcephaly, where the brain size is markedly reduced.

Original languageEnglish
Pages (from-to)516-526
Number of pages11
Journal Journal of Molecular Neuroscience
Issue number3
StatePublished - Mar 2012
Externally publishedYes


  • Brain development
  • Interkinetic nuclear movement
  • Microcephaly


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