Intercontinental spread from Israel to Colombia of a KPC- 3- producing Klebsiella pneumoniae strain

J. A. Lopez; A. Correa; S. Navon- Venezia; A. L. Correa; J. A. Torres; D. F. Briceño; M. C. Montealegre; J. P. Quinn; Y. Carmeli; M. V. Villegas

doi:10.1111/j.1469-0691.2010.03209.x

Intercontinental spread from Israel to Colombia of a KPC- 3- producing Klebsiella pneumoniae strain

J. A. Lopez, A. Correa, S. Navon- Venezia, A. L. Correa, J. A. Torres, D. F. Briceño, M. C. Montealegre, J. P. Quinn, Y. Carmeli, M. V. Villegas

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Abstract

In 2008, an increase in the prevalence of carbapenem- resistant Klebsiella pneumoniae was noted in a 286- bed tertiary case hospital in Colombia, where 84 patients (32 infected and 52 colonized) had positive cultures. The identified index patient came from Israel for a liver transplantation. High level carbapenem resistance was observed. Polymyxin B and tigecycline were the only two antibiotics that remained active. PCR- restriction fragment length polymorphism analysis and sequencing revealed bla_{KPC- 3} in the major clone, which was indistinguishable from the K. pneumoniae carbapenemase- 3- producing clone described previously in Israel. This exemplifies the threat posed by the global spread of K. pneumoniae carbapenemase- producing pathogens.

Original language	English
Pages (from-to)	52-56
Number of pages	5
Journal	Clinical Microbiology and Infection
Volume	17
Issue number	1
DOIs	https://doi.org/10.1111/j.1469-0691.2010.03209.x
State	Published - Jan 2011
Externally published	Yes

Keywords

Colombia
Dissemination
Israel
KPC- 3
Klebsiella pneumoniae

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10.1111/j.1469-0691.2010.03209.x

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title = "Intercontinental spread from Israel to Colombia of a KPC- 3- producing Klebsiella pneumoniae strain",

abstract = "In 2008, an increase in the prevalence of carbapenem- resistant Klebsiella pneumoniae was noted in a 286- bed tertiary case hospital in Colombia, where 84 patients (32 infected and 52 colonized) had positive cultures. The identified index patient came from Israel for a liver transplantation. High level carbapenem resistance was observed. Polymyxin B and tigecycline were the only two antibiotics that remained active. PCR- restriction fragment length polymorphism analysis and sequencing revealed blaKPC- 3 in the major clone, which was indistinguishable from the K. pneumoniae carbapenemase- 3- producing clone described previously in Israel. This exemplifies the threat posed by the global spread of K. pneumoniae carbapenemase- producing pathogens.",

keywords = "Colombia, Dissemination, Israel, KPC- 3, Klebsiella pneumoniae",

author = "Lopez, {J. A.} and A. Correa and {Navon- Venezia}, S. and Correa, {A. L.} and Torres, {J. A.} and Brice{\~n}o, {D. F.} and Montealegre, {M. C.} and Quinn, {J. P.} and Y. Carmeli and Villegas, {M. V.}",

note = "Funding Information: The conformation of the network of institutions from the Colombian Nosocomial Resistance Study Group and funding for this study were made possible thanks in part to the support of: AstraZeneca, Colombia; Pfizer Inc., Groton, CT; Merck Sharp & Dohme, Baxter, Colombia, Wyeth, Colombia,; and Janssen, Colombia. ",

year = "2011",

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doi = "10.1111/j.1469-0691.2010.03209.x",

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AU - Correa, A.

AU - Navon- Venezia, S.

AU - Correa, A. L.

AU - Torres, J. A.

AU - Briceño, D. F.

AU - Montealegre, M. C.

AU - Quinn, J. P.

AU - Carmeli, Y.

AU - Villegas, M. V.

N1 - Funding Information: The conformation of the network of institutions from the Colombian Nosocomial Resistance Study Group and funding for this study were made possible thanks in part to the support of: AstraZeneca, Colombia; Pfizer Inc., Groton, CT; Merck Sharp & Dohme, Baxter, Colombia, Wyeth, Colombia,; and Janssen, Colombia.

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N2 - In 2008, an increase in the prevalence of carbapenem- resistant Klebsiella pneumoniae was noted in a 286- bed tertiary case hospital in Colombia, where 84 patients (32 infected and 52 colonized) had positive cultures. The identified index patient came from Israel for a liver transplantation. High level carbapenem resistance was observed. Polymyxin B and tigecycline were the only two antibiotics that remained active. PCR- restriction fragment length polymorphism analysis and sequencing revealed blaKPC- 3 in the major clone, which was indistinguishable from the K. pneumoniae carbapenemase- 3- producing clone described previously in Israel. This exemplifies the threat posed by the global spread of K. pneumoniae carbapenemase- producing pathogens.

AB - In 2008, an increase in the prevalence of carbapenem- resistant Klebsiella pneumoniae was noted in a 286- bed tertiary case hospital in Colombia, where 84 patients (32 infected and 52 colonized) had positive cultures. The identified index patient came from Israel for a liver transplantation. High level carbapenem resistance was observed. Polymyxin B and tigecycline were the only two antibiotics that remained active. PCR- restriction fragment length polymorphism analysis and sequencing revealed blaKPC- 3 in the major clone, which was indistinguishable from the K. pneumoniae carbapenemase- 3- producing clone described previously in Israel. This exemplifies the threat posed by the global spread of K. pneumoniae carbapenemase- producing pathogens.

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Intercontinental spread from Israel to Colombia of a KPC- 3- producing Klebsiella pneumoniae strain

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Keywords

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