Interactions of drugs with the developing kidney

D. L. Blowey, S. Ben-David, G. Koren

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Interactions between drugs and the kidney are necessary for renal drug elimination, metabolism, and occasionally for therapeutic effect. These interactions may result also in renal toxicity. Understanding the kidney's role in drug-handling helps the clinician to be aware of potential drug interactions and toxicity. Drug disposition, elimination, and toxicity may differ with development and are to be considered when prescribing drugs for children. Nephrotoxicity associated with drugs, although common, is usually reversible with discontinuation of the drug; however, when drug therapy with a well-known nephrotoxic drug (e.g., cisplatin) is necessary, pharmacologic modulators may play a role in limiting the associated nephrotoxicity.

Original languageEnglish
Pages (from-to)1415-1431
Number of pages17
JournalPediatric Clinics of North America
Issue number6
StatePublished - 1995
Externally publishedYes


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