Infrared fiber optic spectroscopy: A novel tool for skin diagnosis

I. Goldberg; A. Shushan; S. Brenner; B. Nadler; Y. Raichlin; E. Shulzinger; L. Gerber; A. Katzir

doi:10.1117/12.528961

Infrared fiber optic spectroscopy: A novel tool for skin diagnosis

I. Goldberg, A. Shushan, S. Brenner, B. Nadler, Y. Raichlin, E. Shulzinger, L. Gerber, A. Katzir

Department of Physics

Research output: Contribution to journal › Conference article › peer-review

5 Scopus citations

Abstract

Fiber Evanescent Wave Spectroscopy (FEWS) is a very useful method for non-invasive and non-destructive biomedical diagnosis. We have developed a FEWS system that makes use of a Fourier Transform Infrared (FTIR) spectrometer and IR transmitting AgBr_xCl_1-x fibers. The FTIR-FEWS system is compact and easy to use, and it is ideal for the study of the spectroscopy of the skin in the mid-IR. The evanescent wave penetration depth in the mid-IR is comparable with the thickness of the stratum corneum, and therefore the vibrational spectra of lipids, proteins and water can be easily analyzed. We have used FTIR-FEWS for a clinical study of the skin of 60 patients, who had some suspicious skin lesions. Preliminary measurements were carried out both on the lesion and on neighboring healthy areas of the skin, showing some differences in the IR absorption. More data is needed in order to determine the possibility of diagnosis of skin cancer and its type from mid-IR spectral data.

Original language	English
Pages (from-to)	44-50
Number of pages	7
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	5321
DOIs	https://doi.org/10.1117/12.528961
State	Published - 2004
Event	Progress in Biomedical Optics and Imaging - Biomedical Vibrational Spectroscopy and Biohazard Detection Technologies - San Jose, CA, United States Duration: 25 Jan 2004 → 27 Jan 2004

Keywords

Ir fibers
Ir spectroscopy
Skin cancer: Melanoma
Skin diagnosis

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10.1117/12.528961

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title = "Infrared fiber optic spectroscopy: A novel tool for skin diagnosis",

abstract = "Fiber Evanescent Wave Spectroscopy (FEWS) is a very useful method for non-invasive and non-destructive biomedical diagnosis. We have developed a FEWS system that makes use of a Fourier Transform Infrared (FTIR) spectrometer and IR transmitting AgBrxCl1-x fibers. The FTIR-FEWS system is compact and easy to use, and it is ideal for the study of the spectroscopy of the skin in the mid-IR. The evanescent wave penetration depth in the mid-IR is comparable with the thickness of the stratum corneum, and therefore the vibrational spectra of lipids, proteins and water can be easily analyzed. We have used FTIR-FEWS for a clinical study of the skin of 60 patients, who had some suspicious skin lesions. Preliminary measurements were carried out both on the lesion and on neighboring healthy areas of the skin, showing some differences in the IR absorption. More data is needed in order to determine the possibility of diagnosis of skin cancer and its type from mid-IR spectral data.",

keywords = "Ir fibers, Ir spectroscopy, Skin cancer: Melanoma, Skin diagnosis",

author = "I. Goldberg and A. Shushan and S. Brenner and B. Nadler and Y. Raichlin and E. Shulzinger and L. Gerber and A. Katzir",

year = "2004",

doi = "10.1117/12.528961",

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T2 - Progress in Biomedical Optics and Imaging - Biomedical Vibrational Spectroscopy and Biohazard Detection Technologies

AU - Goldberg, I.

AU - Shushan, A.

AU - Brenner, S.

AU - Nadler, B.

AU - Raichlin, Y.

AU - Shulzinger, E.

AU - Gerber, L.

AU - Katzir, A.

PY - 2004

Y1 - 2004

N2 - Fiber Evanescent Wave Spectroscopy (FEWS) is a very useful method for non-invasive and non-destructive biomedical diagnosis. We have developed a FEWS system that makes use of a Fourier Transform Infrared (FTIR) spectrometer and IR transmitting AgBrxCl1-x fibers. The FTIR-FEWS system is compact and easy to use, and it is ideal for the study of the spectroscopy of the skin in the mid-IR. The evanescent wave penetration depth in the mid-IR is comparable with the thickness of the stratum corneum, and therefore the vibrational spectra of lipids, proteins and water can be easily analyzed. We have used FTIR-FEWS for a clinical study of the skin of 60 patients, who had some suspicious skin lesions. Preliminary measurements were carried out both on the lesion and on neighboring healthy areas of the skin, showing some differences in the IR absorption. More data is needed in order to determine the possibility of diagnosis of skin cancer and its type from mid-IR spectral data.

AB - Fiber Evanescent Wave Spectroscopy (FEWS) is a very useful method for non-invasive and non-destructive biomedical diagnosis. We have developed a FEWS system that makes use of a Fourier Transform Infrared (FTIR) spectrometer and IR transmitting AgBrxCl1-x fibers. The FTIR-FEWS system is compact and easy to use, and it is ideal for the study of the spectroscopy of the skin in the mid-IR. The evanescent wave penetration depth in the mid-IR is comparable with the thickness of the stratum corneum, and therefore the vibrational spectra of lipids, proteins and water can be easily analyzed. We have used FTIR-FEWS for a clinical study of the skin of 60 patients, who had some suspicious skin lesions. Preliminary measurements were carried out both on the lesion and on neighboring healthy areas of the skin, showing some differences in the IR absorption. More data is needed in order to determine the possibility of diagnosis of skin cancer and its type from mid-IR spectral data.

KW - Ir fibers

KW - Ir spectroscopy

KW - Skin cancer: Melanoma

KW - Skin diagnosis

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Infrared fiber optic spectroscopy: A novel tool for skin diagnosis

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Keywords

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