Ineffectiveness of the 2014-2015 H3N2 influenza vaccine

Michal Mandelboim, Aharona Glatman-Freedman, Yaron Drori, Hilda Sherbany, Rakefet Pando, Hanna Sefty, Hila Zadka, Tamar Shohat, Nathan Keller, Ella Mendelson

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The seasonal influenza vaccine is currently the most effective preventive modality against influenza infection. Nasopharyngeal samples of vaccinated and non-vaccinated patients presenting with Influenza-like-illness (ILI) were collected from over 20 outpatient clinics located in different geographic parts of Israel and were tested for the presence of influenza viruses (influenza A and influenza B). Here we show, that in the 2014-2015 season, the vaccine that included the A/Texas/50/2012 H3N2 virus was ineffective. Significant numbers of individuals vaccinated with the 2014-2015 vaccine, of all ages, were infected with influenza A (H3N2), manifesting similar symptoms as the non-vaccinated group. We further demonstrate that the Israeli circulating influenza A(H3N2) virus was different than that included in the 2014-2015 northern hemisphere vaccine, and that antibodies elicited by this vaccine were significantly less efficient in neutralizing influenza A(H3N2) infection.

Original languageEnglish
Pages (from-to)1185-1192
Number of pages8
Issue number2
StatePublished - 2016


  • Immune response
  • Immunity
  • Immunology and Microbiology Section
  • Influenza
  • Vaccine


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