Increased risk of salivary gland tumors after low-dose irradiation

Baruch Modan, Angela Chetrit, Esther Alfandary, Arnon Tamir, Ayala Lusky, Michael Wolf, Ofer Shpilberg

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Objective: To assess the risk of neoplastic development among persons exposed to scalp irradiation. Study Design: Historical cohort study initially; prospective follow-up subsequently. Method: Two control groups- population and siblings-matched for age, sex, ethnic origin, and year of immigration. Follow-up from time of irradiation (1950s) until the end of 1991. Linkage with nationwide cancer registry. Results: A 4.5-fold incidence of cancer (P < .01) and a 2.6-fold increase of benign tumors were noted. The mean length of latency period until tumor development was 11 years for malignant tumors and 21.5 years for benign. A clear dose response effect for both cancer and benign tumors was demonstrated. Conclusions: The study confirms the role of radiation in salivary gland carcinogenesis. It indicates a need for better awareness, a comprehensive examination, and long-term follow-up of patients who have been subjected to head and neck radiation.

Original languageEnglish
Pages (from-to)1095-1097
Number of pages3
Issue number7
StatePublished - Jul 1998
Externally publishedYes


  • Carcinogenesis
  • Radiation
  • Salivary glands
  • Screening


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