Increased Rate of Familial Mediterranean Fever in Children With ADHD: A Population-Based Case-Control Study

Eugene Merzon; Ariel Israel; Beth Krone; Shani Medvejer; Shira Cohen; Ilan Green; Avivit Golan-Cohen; Shlomo Vinker; Stephen V. Faraone; Jeffrey H. Newcorn; Shai Ashkenazi; Abraham Weizman; Iris Manor

doi:10.1177/10870547231215045

Increased Rate of Familial Mediterranean Fever in Children With ADHD: A Population-Based Case-Control Study

Eugene Merzon, Ariel Israel, Beth Krone, Shani Medvejer, Shira Cohen, Ilan Green, Avivit Golan-Cohen, Shlomo Vinker, Stephen V. Faraone, Jeffrey H. Newcorn, Shai Ashkenazi, Abraham Weizman, Iris Manor

Adelson School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: There is growing evidence of involvement of inflammatory mechanisms in ADHD. Previous studies found significantly higher rates of ADHD among children with FMF. The present study examined the rate of exposure to FMF in children with a later (within a 5-year period) diagnosis of ADHD compared to non-ADHD children. Methods: A population-based case-control study of all children (<18 years) registered in Leumit Health Services during 01.01.2006 to 06.30.2021. All cases met ICD-9/10 criteria for ADHD. They were matched by age, sex, and socioeconomic status on a 1:2 rate to randomly selected non-ADHD controls. Results: Fifty-six (0.30%) children with ADHD (N = 18,756) were previously diagnosed with FMF compared to 65 of 37,512 controls (0.17%). A significant, independent association existed between a preceding FMF diagnosis and a later ADHD diagnosis [OR = 1.72 (95% CI 1.18–2.51); p =.003]. Conclusions: The mechanisms underlying the association w between FMF and later ADHD diagnosis merit further elucidation.

Original language	English
Pages (from-to)	669-676
Number of pages	8
Journal	Journal of Attention Disorders
Volume	28
Issue number	5
DOIs	https://doi.org/10.1177/10870547231215045
State	Published - Mar 2024

Keywords

ADHD
FMF
autoimmune
neuro-inflammation

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Merzon, E., Israel, A., Krone, B., Medvejer, S., Cohen, S., Green, I., Golan-Cohen, A., Vinker, S., Faraone, S. V., Newcorn, J. H., Ashkenazi, S., Weizman, A., & Manor, I. (2024). Increased Rate of Familial Mediterranean Fever in Children With ADHD: A Population-Based Case-Control Study. Journal of Attention Disorders, 28(5), 669-676. https://doi.org/10.1177/10870547231215045

@article{0740f897184a4c91908d0af715d8d4e3,

title = "Increased Rate of Familial Mediterranean Fever in Children With ADHD: A Population-Based Case-Control Study",

abstract = "Objective: There is growing evidence of involvement of inflammatory mechanisms in ADHD. Previous studies found significantly higher rates of ADHD among children with FMF. The present study examined the rate of exposure to FMF in children with a later (within a 5-year period) diagnosis of ADHD compared to non-ADHD children. Methods: A population-based case-control study of all children (<18 years) registered in Leumit Health Services during 01.01.2006 to 06.30.2021. All cases met ICD-9/10 criteria for ADHD. They were matched by age, sex, and socioeconomic status on a 1:2 rate to randomly selected non-ADHD controls. Results: Fifty-six (0.30%) children with ADHD (N = 18,756) were previously diagnosed with FMF compared to 65 of 37,512 controls (0.17%). A significant, independent association existed between a preceding FMF diagnosis and a later ADHD diagnosis [OR = 1.72 (95% CI 1.18–2.51); p =.003]. Conclusions: The mechanisms underlying the association w between FMF and later ADHD diagnosis merit further elucidation.",

keywords = "ADHD, FMF, autoimmune, neuro-inflammation",

author = "Eugene Merzon and Ariel Israel and Beth Krone and Shani Medvejer and Shira Cohen and Ilan Green and Avivit Golan-Cohen and Shlomo Vinker and Faraone, {Stephen V.} and Newcorn, {Jeffrey H.} and Shai Ashkenazi and Abraham Weizman and Iris Manor",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2023.",

year = "2024",

month = mar,

doi = "10.1177/10870547231215045",

language = "אנגלית",

volume = "28",

pages = "669--676",

journal = "Journal of Attention Disorders",

issn = "1087-0547",

publisher = "SAGE Publications Inc.",

number = "5",

}

Merzon, E, Israel, A, Krone, B, Medvejer, S, Cohen, S, Green, I, Golan-Cohen, A, Vinker, S, Faraone, SV, Newcorn, JH, Ashkenazi, S, Weizman, A & Manor, I 2024, 'Increased Rate of Familial Mediterranean Fever in Children With ADHD: A Population-Based Case-Control Study', Journal of Attention Disorders, vol. 28, no. 5, pp. 669-676. https://doi.org/10.1177/10870547231215045

TY - JOUR

T1 - Increased Rate of Familial Mediterranean Fever in Children With ADHD

T2 - A Population-Based Case-Control Study

AU - Merzon, Eugene

AU - Israel, Ariel

AU - Krone, Beth

AU - Medvejer, Shani

AU - Cohen, Shira

AU - Green, Ilan

AU - Golan-Cohen, Avivit

AU - Vinker, Shlomo

AU - Faraone, Stephen V.

AU - Newcorn, Jeffrey H.

AU - Ashkenazi, Shai

AU - Weizman, Abraham

AU - Manor, Iris

PY - 2024/3

Y1 - 2024/3

N2 - Objective: There is growing evidence of involvement of inflammatory mechanisms in ADHD. Previous studies found significantly higher rates of ADHD among children with FMF. The present study examined the rate of exposure to FMF in children with a later (within a 5-year period) diagnosis of ADHD compared to non-ADHD children. Methods: A population-based case-control study of all children (<18 years) registered in Leumit Health Services during 01.01.2006 to 06.30.2021. All cases met ICD-9/10 criteria for ADHD. They were matched by age, sex, and socioeconomic status on a 1:2 rate to randomly selected non-ADHD controls. Results: Fifty-six (0.30%) children with ADHD (N = 18,756) were previously diagnosed with FMF compared to 65 of 37,512 controls (0.17%). A significant, independent association existed between a preceding FMF diagnosis and a later ADHD diagnosis [OR = 1.72 (95% CI 1.18–2.51); p =.003]. Conclusions: The mechanisms underlying the association w between FMF and later ADHD diagnosis merit further elucidation.

AB - Objective: There is growing evidence of involvement of inflammatory mechanisms in ADHD. Previous studies found significantly higher rates of ADHD among children with FMF. The present study examined the rate of exposure to FMF in children with a later (within a 5-year period) diagnosis of ADHD compared to non-ADHD children. Methods: A population-based case-control study of all children (<18 years) registered in Leumit Health Services during 01.01.2006 to 06.30.2021. All cases met ICD-9/10 criteria for ADHD. They were matched by age, sex, and socioeconomic status on a 1:2 rate to randomly selected non-ADHD controls. Results: Fifty-six (0.30%) children with ADHD (N = 18,756) were previously diagnosed with FMF compared to 65 of 37,512 controls (0.17%). A significant, independent association existed between a preceding FMF diagnosis and a later ADHD diagnosis [OR = 1.72 (95% CI 1.18–2.51); p =.003]. Conclusions: The mechanisms underlying the association w between FMF and later ADHD diagnosis merit further elucidation.

KW - ADHD

KW - FMF

KW - autoimmune

KW - neuro-inflammation

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JO - Journal of Attention Disorders

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ER -

Increased Rate of Familial Mediterranean Fever in Children With ADHD: A Population-Based Case-Control Study

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