Increased concanavalin A-induced suppressor cell activity in humans with occupational lead exposure

Natan Cohen; David Modai; Ahuva Golik; Joshua Weissgarten; Shoshana Peller; Avi Katz; Zhan Averbukh; Uri Shaked

doi:10.1016/S0013-9351(89)80079-9

Increased concanavalin A-induced suppressor cell activity in humans with occupational lead exposure

Natan Cohen
, David Modai
, Ahuva Golik
, Joshua Weissgarten
, Shoshana Peller
, Avi Katz
, Zhan Averbukh
, Uri Shaked

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

E-rosette-forming cells (E-RFC), mitogen-induced blast transformation, OKT4⁺, OKT8⁺ cells, and their ratio were found to be normal in 10 subjects chronically exposed to lead with blood levels of 40-51 μg%. However, concanavalin A (Con A)-induced suppressor cell activity (SCA) in these subjects was significantly greater than in normal matched controls. The clinical relevance of this observation is not clear, but it may have some bearing on the various immunologic defects described in lead exposure.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Environmental Research
Volume	48
Issue number	1
DOIs	https://doi.org/10.1016/S0013-9351(89)80079-9
State	Published - Feb 1989
Externally published	Yes

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title = "Increased concanavalin A-induced suppressor cell activity in humans with occupational lead exposure",

abstract = "E-rosette-forming cells (E-RFC), mitogen-induced blast transformation, OKT4+, OKT8+ cells, and their ratio were found to be normal in 10 subjects chronically exposed to lead with blood levels of 40-51 μg\%. However, concanavalin A (Con A)-induced suppressor cell activity (SCA) in these subjects was significantly greater than in normal matched controls. The clinical relevance of this observation is not clear, but it may have some bearing on the various immunologic defects described in lead exposure.",

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AU - Katz, Avi

AU - Averbukh, Zhan

AU - Shaked, Uri

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Increased concanavalin A-induced suppressor cell activity in humans with occupational lead exposure

Abstract

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