TY - JOUR
T1 - Increased concanavalin A-induced suppressor cell activity in humans with occupational lead exposure
AU - Cohen, Natan
AU - Modai, David
AU - Golik, Ahuva
AU - Weissgarten, Joshua
AU - Peller, Shoshana
AU - Katz, Avi
AU - Averbukh, Zhan
AU - Shaked, Uri
PY - 1989/2
Y1 - 1989/2
N2 - E-rosette-forming cells (E-RFC), mitogen-induced blast transformation, OKT4+, OKT8+ cells, and their ratio were found to be normal in 10 subjects chronically exposed to lead with blood levels of 40-51 μg%. However, concanavalin A (Con A)-induced suppressor cell activity (SCA) in these subjects was significantly greater than in normal matched controls. The clinical relevance of this observation is not clear, but it may have some bearing on the various immunologic defects described in lead exposure.
AB - E-rosette-forming cells (E-RFC), mitogen-induced blast transformation, OKT4+, OKT8+ cells, and their ratio were found to be normal in 10 subjects chronically exposed to lead with blood levels of 40-51 μg%. However, concanavalin A (Con A)-induced suppressor cell activity (SCA) in these subjects was significantly greater than in normal matched controls. The clinical relevance of this observation is not clear, but it may have some bearing on the various immunologic defects described in lead exposure.
UR - http://www.scopus.com/inward/record.url?scp=0024555657&partnerID=8YFLogxK
U2 - 10.1016/S0013-9351(89)80079-9
DO - 10.1016/S0013-9351(89)80079-9
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C2 - 2521599
AN - SCOPUS:0024555657
SN - 0013-9351
VL - 48
SP - 1
EP - 6
JO - Environmental Research
JF - Environmental Research
IS - 1
ER -