TY - JOUR
T1 - Increased anti-Sm antibodies in schizophrenic patients and their families
AU - Sirota, Pinkhas
AU - Firer, Michael
AU - Schild, Klara
AU - Zurgil, Neomi
AU - Barak, Yoram
AU - Elizur, Avner
AU - Slor, Hanoch
PY - 1993/9
Y1 - 1993/9
N2 - Sirota, Pinkhas, Michael Firer, Klara Schield, Neomi Zurgil, Yoram Barak, Avner Elizur and Hanoch Slor: Increased Anti-Sm Antibodies in Schizophrenic Patients and their Families. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1993, 17(5): 793-800. 1. 1. Autoantibodies in the Sm complex have become a useful serologic aid in the diagnosis of systemic lupus erythematosus (SLE) and have rarely been observed in other diseases. 2. 2. A subset of SLE patients have a variety of psychiatric abnormalities, including schizophrenia. 3. 3. The authors have recently observed that schizophrenic patients have a high incidence of autoantibodies suggesting that autoimmune phenomena may play a role in the pathogenesis of this disease. 4. 4. In the present study the authors investigated multicase families with schizo- phrenia for the presence of anti-Sm antibodies and showed that these autoanti- bodies are elevated both in patients and in their healthy relatives. 5. 5. An autoimmune process may be involved in the pathology of schizophrenia.
AB - Sirota, Pinkhas, Michael Firer, Klara Schield, Neomi Zurgil, Yoram Barak, Avner Elizur and Hanoch Slor: Increased Anti-Sm Antibodies in Schizophrenic Patients and their Families. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1993, 17(5): 793-800. 1. 1. Autoantibodies in the Sm complex have become a useful serologic aid in the diagnosis of systemic lupus erythematosus (SLE) and have rarely been observed in other diseases. 2. 2. A subset of SLE patients have a variety of psychiatric abnormalities, including schizophrenia. 3. 3. The authors have recently observed that schizophrenic patients have a high incidence of autoantibodies suggesting that autoimmune phenomena may play a role in the pathogenesis of this disease. 4. 4. In the present study the authors investigated multicase families with schizo- phrenia for the presence of anti-Sm antibodies and showed that these autoanti- bodies are elevated both in patients and in their healthy relatives. 5. 5. An autoimmune process may be involved in the pathology of schizophrenia.
KW - anti-Sm antibodies
KW - autoimmmunity
KW - schizophrenia
KW - schizophrenic families
UR - http://www.scopus.com/inward/record.url?scp=0027327377&partnerID=8YFLogxK
U2 - 10.1016/0278-5846(93)90061-V
DO - 10.1016/0278-5846(93)90061-V
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C2 - 8255987
AN - SCOPUS:0027327377
SN - 0278-5846
VL - 17
SP - 793
EP - 800
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
IS - 5
ER -