TY - JOUR
T1 - Incidental asthma prevention by immune serum globulin
AU - Mimouni, Daniel
AU - Gdalevich, Michael
AU - Mimouni, Karin
AU - Mimouni, Francis B.
AU - Eldad, Arieh
AU - Shpilberg, Ofer
PY - 2002/7/1
Y1 - 2002/7/1
N2 - Background: After a case of hepatitis A in a food handling worker in a military base, the entire exposed population was vaccinated with immune serum globulin (ISG). We analyzed the potential effects of ISG on asthma attacks and respiratory infections. Methods: The base population was observed for asthma exacerbation for the 3 months after the immunization and was compared with the population of the same base a year earlier. Rates were tested using X2 statistics. Results: The vaccinated population had a highly significant decrease in the incidence of asthma attacks (rate ratio [RR] = 0.2, 95% confidence interval [CI] 0.09 to 0.45), sinusitis (RR = 0.34, 95% CI 0.2 to 0.58), and pneumonia (RR = 0.41, 95% CI 0.17 to 0.99). No significant difference was observed in the incidence rates of upper respiratory infections between the two groups. Conclusions: A single administration of ISG significantly reduces the rate of asthma attacks and respiratory infections.
AB - Background: After a case of hepatitis A in a food handling worker in a military base, the entire exposed population was vaccinated with immune serum globulin (ISG). We analyzed the potential effects of ISG on asthma attacks and respiratory infections. Methods: The base population was observed for asthma exacerbation for the 3 months after the immunization and was compared with the population of the same base a year earlier. Rates were tested using X2 statistics. Results: The vaccinated population had a highly significant decrease in the incidence of asthma attacks (rate ratio [RR] = 0.2, 95% confidence interval [CI] 0.09 to 0.45), sinusitis (RR = 0.34, 95% CI 0.2 to 0.58), and pneumonia (RR = 0.41, 95% CI 0.17 to 0.99). No significant difference was observed in the incidence rates of upper respiratory infections between the two groups. Conclusions: A single administration of ISG significantly reduces the rate of asthma attacks and respiratory infections.
UR - http://www.scopus.com/inward/record.url?scp=0036666647&partnerID=8YFLogxK
U2 - 10.1016/S1081-1206(10)61918-7
DO - 10.1016/S1081-1206(10)61918-7
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C2 - 12141729
AN - SCOPUS:0036666647
SN - 1081-1206
VL - 89
SP - 99
EP - 100
JO - Annals of Allergy, Asthma and Immunology
JF - Annals of Allergy, Asthma and Immunology
IS - 1
ER -