In vitro testing for hypersensitivity-mediated adverse drug reactions: Challenges and future directions

A. A. Elzagallaai, G. Koren, J. R. Bend, M. J. Rieder

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Drug hypersensitivity reactions (DHRs) are uncommon but potentially fatal adverse events. Their diagnosis and prediction are difficult given their variable presentation and the overlap of symptoms with those of other clinical conditions. Systemic rechallenge is considered the gold standard for the diagnosis of DHRs; however, this may have severe consequences. In vitro tests are currently not sufficiently reliable to provide the basis for clinical decisions. This article summarizes the challenges associated with in vitro testing for DHRs.

Original languageEnglish
Pages (from-to)455-460
Number of pages6
JournalClinical Pharmacology and Therapeutics
Volume90
Issue number3
DOIs
StatePublished - Sep 2011
Externally publishedYes

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