In vitro analysis of human transplacental transport of desmopressin

Joel G. Ray, Rada Boskovic, Brenda Knie, Marjie Hard, Galina Portnoi, Gideon Koren

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Objective: Desmopressin (DDAVP) therapy may be required during pregnancy, but there are limited data about its safety. We wished to verify whether DDAVP is transported across the human placenta. Methods: Using the in vitro human placental cotyledon perfusion model, we performed serial measurements of maternal and fetal DDAVP concentrations. After introducing the drug into the maternal circulation at estimated baseline therapeutic (30 pg/ml) and supratherapeutic (16,000 and 60,000 pg/ml) concentrations, we measured the rate of transplacental drug transfer up to 2 h. Results: There was no detectable transport of DDAVP at a 30 pg/ml concentration, and the maternal drug concentration remained stable over time. At a much higher maternal concentration of 60,000 pg/ml, the mean peak fetal DDAVP concentration was 2990 pg/ml, equivalent to 4.8% of the baseline maternal concentration. Conclusion: At a therapeutic maternal drug concentration, DDAVP does not appear to cross the placenta within detectable limits. At much higher drug concentrations, DDAVP may cross the placenta in a small amount. Future in vitro clinical studies should attempt to reproduce these findings.

Original languageEnglish
Pages (from-to)10-13
Number of pages4
JournalClinical Biochemistry
Volume37
Issue number1
DOIs
StatePublished - Jan 2004
Externally publishedYes

Keywords

  • Arginine vasopressin
  • DDAVP
  • Desmopressin
  • Diabetes insipidus
  • Fetus
  • Placenta
  • Placental perfusion
  • Pregnancy
  • Von Willebrand disease

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