TY - JOUR
T1 - In vitro activity of levofloxacin against Helicobacter pylori isolates from patients after treatment failure
AU - Yahav, Jacob
AU - Shmuely, Haim
AU - Niv, Yaron
AU - Bechor, Jacklin
AU - Samra, Zmira
PY - 2006/5
Y1 - 2006/5
N2 - We tested the in vitro activity of levofloxacin (LEV), amoxicillin (AMP), clarithromycin (CLA), metronidazole (MET), and tetracycline (TET) against 70 clinical isolates of Helicobacter pylori recovered from 70 dyspeptic patients. All patients had previously failed 2 treatment regimens: first-line triple therapy with omeprazole, AMP, and CLA, and second-line quadruple therapy with omeprazole, MET, TET, and bismuth. Resistance to CLA, MET, and LEV was found in 65.7%, 57.1%, and 18.6% of isolates, respectively. Resistance to both CLA and MET was found in 32.8%, and to CLA, MET, and LEV in 12.8%. Only 4 of the isolates were resistant to both CLA and LEV, and none was resistant to LEV alone or to MET and LEV. Physicians should consider triple therapy with omeprazole, LEV, and AMP in patients unsuccessfully treated with first- and second-line regimens.
AB - We tested the in vitro activity of levofloxacin (LEV), amoxicillin (AMP), clarithromycin (CLA), metronidazole (MET), and tetracycline (TET) against 70 clinical isolates of Helicobacter pylori recovered from 70 dyspeptic patients. All patients had previously failed 2 treatment regimens: first-line triple therapy with omeprazole, AMP, and CLA, and second-line quadruple therapy with omeprazole, MET, TET, and bismuth. Resistance to CLA, MET, and LEV was found in 65.7%, 57.1%, and 18.6% of isolates, respectively. Resistance to both CLA and MET was found in 32.8%, and to CLA, MET, and LEV in 12.8%. Only 4 of the isolates were resistant to both CLA and LEV, and none was resistant to LEV alone or to MET and LEV. Physicians should consider triple therapy with omeprazole, LEV, and AMP in patients unsuccessfully treated with first- and second-line regimens.
KW - Helicobacter pylori
KW - In vitro susceptibility, treatment
KW - Levofloxacin
UR - http://www.scopus.com/inward/record.url?scp=33646469364&partnerID=8YFLogxK
U2 - 10.1016/j.diagmicrobio.2005.12.003
DO - 10.1016/j.diagmicrobio.2005.12.003
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C2 - 16490341
AN - SCOPUS:33646469364
SN - 0732-8893
VL - 55
SP - 81
EP - 83
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
IS - 1
ER -