Improved antimicrobial peptides based on acyl-lysine oligomers

Inna S. Radzishevsky; Shahar Rotem; Dmitry Bourdetsky; Shiri Navon-Venezia; Yehuda Carmeli; Amram Mor

doi:10.1038/nbt1309

Improved antimicrobial peptides based on acyl-lysine oligomers

Inna S. Radzishevsky
, Shahar Rotem
, Dmitry Bourdetsky
, Shiri Navon-Venezia
, Yehuda Carmeli
, Amram Mor

Research output: Contribution to journal › Article › peer-review

246 Scopus citations

Abstract

We describe peptidomimetic oligomers that show rapid, nonhemolytic, broad-spectrum bactericidal properties in mice and do not induce the emergence of resistance. The oligomers contain acyl chains, which prevent the formation of stable secondary structure. This design appears advantageous over conventional antimicrobial peptides with respect to in vivo efficacy and safety, and may provide a convenient platform for the development of peptide antibiotics.

Original language	English
Pages (from-to)	657-659
Number of pages	3
Journal	Nature Biotechnology
Volume	25
Issue number	6
DOIs	https://doi.org/10.1038/nbt1309
State	Published - Jun 2007
Externally published	Yes

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10.1038/nbt1309

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abstract = "We describe peptidomimetic oligomers that show rapid, nonhemolytic, broad-spectrum bactericidal properties in mice and do not induce the emergence of resistance. The oligomers contain acyl chains, which prevent the formation of stable secondary structure. This design appears advantageous over conventional antimicrobial peptides with respect to in vivo efficacy and safety, and may provide a convenient platform for the development of peptide antibiotics.",

author = "Radzishevsky, \{Inna S.\} and Shahar Rotem and Dmitry Bourdetsky and Shiri Navon-Venezia and Yehuda Carmeli and Amram Mor",

note = "Funding Information: This work was supported by The Israel Science Foundation (grant no. 387/03) and by BiolineRx (grant no. 2006992).",

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AU - Radzishevsky, Inna S.

AU - Rotem, Shahar

AU - Bourdetsky, Dmitry

AU - Navon-Venezia, Shiri

AU - Carmeli, Yehuda

AU - Mor, Amram

N1 - Funding Information: This work was supported by The Israel Science Foundation (grant no. 387/03) and by BiolineRx (grant no. 2006992).

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AB - We describe peptidomimetic oligomers that show rapid, nonhemolytic, broad-spectrum bactericidal properties in mice and do not induce the emergence of resistance. The oligomers contain acyl chains, which prevent the formation of stable secondary structure. This design appears advantageous over conventional antimicrobial peptides with respect to in vivo efficacy and safety, and may provide a convenient platform for the development of peptide antibiotics.

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Improved antimicrobial peptides based on acyl-lysine oligomers

Abstract

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