Hydrochlorothiazide-amiloride causes excessive urinary zinc excretion

Ahuva Golik; David Modai; Joshua Weissgarten; Natan Cohen; Zhan Averbukh; Erika Sigler; Ronit Zaidenstein; Uri Shaked

doi:10.1038/clpt.1987.105

Hydrochlorothiazide-amiloride causes excessive urinary zinc excretion

Ahuva Golik
, David Modai
, Joshua Weissgarten
, Natan Cohen
, Zhan Averbukh
, Erika Sigler
, Ronit Zaidenstein
, Uri Shaked

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Serum zinc levels and urinary zinc excretion were compared in 15 patients with essential hypertension taking chronically a combination of hydrochlorothiazide and amiloride as monotherapy, eight patients maintained with hydrochlorothiazide alone, and eight control subjects. Serum zinc values were statistically comparable in all three groups. However, urinary zinc excretion was abnormally elevated in the two patient groups. In the dosage used, amiloride did not have a zinc-sparing effect.

Original language	English
Pages (from-to)	42-44
Number of pages	3
Journal	Clinical Pharmacology and Therapeutics
Volume	42
Issue number	1
DOIs	https://doi.org/10.1038/clpt.1987.105
State	Published - Jul 1987
Externally published	Yes

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10.1038/clpt.1987.105

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AU - Golik, Ahuva

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AU - Weissgarten, Joshua

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AU - Sigler, Erika

AU - Zaidenstein, Ronit

AU - Shaked, Uri

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AB - Serum zinc levels and urinary zinc excretion were compared in 15 patients with essential hypertension taking chronically a combination of hydrochlorothiazide and amiloride as monotherapy, eight patients maintained with hydrochlorothiazide alone, and eight control subjects. Serum zinc values were statistically comparable in all three groups. However, urinary zinc excretion was abnormally elevated in the two patient groups. In the dosage used, amiloride did not have a zinc-sparing effect.

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Hydrochlorothiazide-amiloride causes excessive urinary zinc excretion

Abstract

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