TY - JOUR
T1 - Human teratogens and evidence-based teratogen risk counseling
T2 - The Motherisk approach
AU - Nava-Ocampo, Alejandro A.
AU - Koren, Gideon
PY - 2007/3
Y1 - 2007/3
N2 - There are only a limited number of drugs proven to be human teratogens including thalidomide, isotretinoin, coumarin derivates, valproic acid, and folate antagonists. In some cases, the combination of 2 drugs may increase the teratogenic risk. The risk of birth defects may also vary with the time at which the drug is administered during pregnancy and the dose. There are some examples of drugs in which the dose has proven to be a major determinant of their teratogenicity in humans. There is more safety information for older than for newer drugs. Proactive teratogen risk counseling should include a critical appraisal of all available data including the consequences of the untreated maternal condition.
AB - There are only a limited number of drugs proven to be human teratogens including thalidomide, isotretinoin, coumarin derivates, valproic acid, and folate antagonists. In some cases, the combination of 2 drugs may increase the teratogenic risk. The risk of birth defects may also vary with the time at which the drug is administered during pregnancy and the dose. There are some examples of drugs in which the dose has proven to be a major determinant of their teratogenicity in humans. There is more safety information for older than for newer drugs. Proactive teratogen risk counseling should include a critical appraisal of all available data including the consequences of the untreated maternal condition.
KW - Maternal fetal relations
KW - Maternal health services
KW - Prenatal care
KW - Risk-benefit assessment
UR - http://www.scopus.com/inward/record.url?scp=33847114324&partnerID=8YFLogxK
U2 - 10.1097/GRF.0b013e31802f1880
DO - 10.1097/GRF.0b013e31802f1880
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C2 - 17304029
AN - SCOPUS:33847114324
SN - 0009-9201
VL - 50
SP - 123
EP - 131
JO - Clinical Obstetrics and Gynecology
JF - Clinical Obstetrics and Gynecology
IS - 1
ER -