Human and porcine early kidney precursors as a new source for transplantation

Benjamin Dekel, Tatyana Burakova, Fabian D. Arditti, Shlomit Reich-Zeliger, Oren Milstein, Sarit Aviel-Ronen, Gideon Rechavi, Nir Friedman, Naftali Kaminski, Justen H. Passwell, Yair Reisner

Research output: Contribution to journalArticlepeer-review

257 Scopus citations

Abstract

Kidney transplantation has been one of the major medical advances of the past 30 years. However, tissue availability remains a major obstacle. This can potentially be overcome by the use of undifferentiated or partially developed kidney precursor cells derived from early embryos and fetal tissue. Here, transplantation in mice reveals the earliest gestational time point at which kidney precursor cells, of both human and pig origin, differentiate into functional nephrons and not into other, non-renal professional cell types. Moreover, successful organogenesis is achieved when using the early kidney precursors, but not later-gestation kidneys. The formed, miniature kidneys are functional as evidenced by the dilute urine they produce. In addition, decreased immunogenicity of the transplants of early human and pig kidney precursors compared with adult kidney transplants is demonstrated in vivo. Our data pinpoint a window of human and pig kidney organogenesis that may be optimal for transplantation in humans.

Original languageEnglish
Pages (from-to)53-60
Number of pages8
JournalNature Medicine
Volume9
Issue number1
DOIs
StatePublished - 1 Jan 2003
Externally publishedYes

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