Human ACE I/D polymorphism is associated with individual differences in exercise heat tolerance

Yuval Heled, Daniel S. Moran, Liran Mendel, Arie Laor, Elon Pras, Yair Shapiro

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


We hypothesized that there is an association between the angiotensin I-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism with the variability in exercise heat tolerance in humans. Fifty-eight Caucasian men were exposed to a 2-h exercise heat-tolerance test. We analyzed the association between their heat-tolerance levels with the ACE DD (n = 25) and I+ (n = 33) genotypes and with various anthropometrical parameters and aerobic fitness. It was found that the relative changes in body core temperature, heat storage, and heart rate during the 120-min exposure to exercise heat stress was consistently lower in the I+ genotype group compared with the DD genotype group (0.8 ± 0.2 vs. 0.1 °C, P < 0.05; 17.7 ± 1.8 vs. 19.8 ± 1.3 W/M2, P < 0.05; and 33 ± 7 vs. 44 ± 5 beats/min, respectively, P = 0.06). No significant association was found between heat strain response and the anthropometrical measurements or aerobic fitness in the various genotype groups. We suggest that the ACE I+ polymorphism may be considered as a possible candidate marker for increased heat tolerance.

Original languageEnglish
Pages (from-to)72-76
Number of pages5
JournalJournal of Applied Physiology
Issue number1
StatePublished - Jul 2004
Externally publishedYes


  • Angiotensin-converting enzyme polymorphism
  • Exercise
  • Genetics
  • Heat stress
  • Thermoregulation


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