Hsp70 in cancer: Back to the future

M. Y. Sherman, V. L. Gabai

Research output: Contribution to journalReview articlepeer-review

174 Scopus citations

Abstract

Mechanistic studies from cell culture and animal models have revealed critical roles for the heat shock protein Hsp70 in cancer initiation and progression. Surprisingly, many effects of Hsp70 on cancer have not been related to its chaperone activity, but rather to its role(s) in regulating cell signaling. A major factor that directs Hsp70 signaling activity appears to be the co-chaperone Bag3. Here, we review these recent breakthroughs, and how these discoveries drive drug development efforts.

Original languageEnglish
Pages (from-to)4153-4161
Number of pages9
JournalOncogene
Volume34
Issue number32
DOIs
StatePublished - 6 Aug 2015
Externally publishedYes

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