Hsp70 in cancer: Back to the future

M. Y. Sherman; V. L. Gabai

doi:10.1038/onc.2014.349

Hsp70 in cancer: Back to the future

M. Y. Sherman, V. L. Gabai

Research output: Contribution to journal › Review article › peer-review

180 Scopus citations

Abstract

Mechanistic studies from cell culture and animal models have revealed critical roles for the heat shock protein Hsp70 in cancer initiation and progression. Surprisingly, many effects of Hsp70 on cancer have not been related to its chaperone activity, but rather to its role(s) in regulating cell signaling. A major factor that directs Hsp70 signaling activity appears to be the co-chaperone Bag3. Here, we review these recent breakthroughs, and how these discoveries drive drug development efforts.

Original language	English
Pages (from-to)	4153-4161
Number of pages	9
Journal	Oncogene
Volume	34
Issue number	32
DOIs	https://doi.org/10.1038/onc.2014.349
State	Published - 6 Aug 2015
Externally published	Yes

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10.1038/onc.2014.349

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Hsp70 in cancer: Back to the future

Abstract

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