TY - JOUR
T1 - Hormonal evaluation and autoimmune background in pruritic urticarial papules and plaques of pregnancy
AU - Alcalay, Joseph
AU - Ingber, Arieh
AU - Kafri, Batia
AU - Segal, Jacob
AU - Kaufmann, Hayuta
AU - Hazaz, Bilha
AU - Sandbank, Miriam
PY - 1988/12
Y1 - 1988/12
N2 - There is little insight into the pathogenesis of most of the dermatoses specifically associated with pregnancy. We evaluated the hormonal profile and the autoimmune background in 11 pregnant women with pruritic urticarial papules and plaques of pregnancy. No statistically significant difference was found between the serum levels of the β-subunit of human chorionic gonadotropin, estradiol, cortisol, and urinary estriol of the patients and gestational age-matched control subjects. No autoantibodies were found in the patients' group. We conclude that patients with pruritic urticarial papules and plaques of pregnancy have no hormonal alterations when compared with normal pregnant women and that no known major autoimmune background plays a part in the pathogenesis of the disease.
AB - There is little insight into the pathogenesis of most of the dermatoses specifically associated with pregnancy. We evaluated the hormonal profile and the autoimmune background in 11 pregnant women with pruritic urticarial papules and plaques of pregnancy. No statistically significant difference was found between the serum levels of the β-subunit of human chorionic gonadotropin, estradiol, cortisol, and urinary estriol of the patients and gestational age-matched control subjects. No autoantibodies were found in the patients' group. We conclude that patients with pruritic urticarial papules and plaques of pregnancy have no hormonal alterations when compared with normal pregnant women and that no known major autoimmune background plays a part in the pathogenesis of the disease.
KW - Pruritic urticarial papules
KW - autoantibodies
KW - hormonal profile
KW - plaques of pregnancy
UR - http://www.scopus.com/inward/record.url?scp=0023865446&partnerID=8YFLogxK
U2 - 10.1016/0002-9378(88)90168-8
DO - 10.1016/0002-9378(88)90168-8
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C2 - 2449080
AN - SCOPUS:0023865446
SN - 0002-9378
VL - 158
SP - 417
EP - 420
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 2
ER -