Homocysteine, folate and pregnancy outcomes

M. W. Kim, S. C. Hong, J. S. Choi, J. Y. Han, M. J. Oh, H. J. Kim, A. Nava-Ocampo, G. Koren

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


The purpose of this study is to evaluate the relationship between maternal and/or cord blood folate/homocysteine concentrations and adverse pregnancy outcomes. The study population included a random sample of singleton pregnant women in whom we measured total homocysteine and folic acid in maternal or cord blood at deliveries. A total of 227 pregnant women were enrolled. The concentration of folate in maternal blood tended to be significantly lower in pre-term birth than in full-term delivery group (median (95% CI), 14.4 (3.673) vs 25 (7.3105.5) p <0.01). The total homocysteine in maternal and cord blood was significantly higher in the pre-eclampsia than in the normotensive group (7.9 (1.728.2) vs 5.9 (1.814.6) μmol/ml, p <0.05; and 5.8 (2.614.4) vs 4.2 (0.77.9) ng/ml, p <0.05, respectively). Lower maternal serum folate concentration is associated with pre-term delivery and higher maternal plasma homocysteine concentration with pre-eclampsia.

Original languageEnglish
Pages (from-to)520-524
Number of pages5
JournalJournal of Obstetrics and Gynaecology
Issue number6
StatePublished - Aug 2012
Externally publishedYes


  • Folate
  • Homocysteine
  • Pre-term delivery
  • Pregnancy outcomes


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