TY - JOUR
T1 - Hodgkin's variant of Richter transformation in chronic lymphocytic leukemia; a retrospective study from the Israeli CLL study group
AU - Tadmor, Tamar
AU - Shvidel, Lev
AU - Goldschmidt, Neta
AU - Ruchlemer, Rosa
AU - Fineman, Riva
AU - Bairey, Osnat
AU - Rahimi-Levene, Naomi
AU - Herishanu, Yair
AU - Yuklea, Mona
AU - Arad, Ariela
AU - Aviv, Ariel
AU - Polliack, Aaron
N1 - Publisher Copyright:
© 2014, International Institute of Anticancer Research. All rights reserved.
PY - 2014/2/1
Y1 - 2014/2/1
N2 - Backround: Richter syndrome (RS) is the development of an aggressive lymphoid malignancy, in chronic lymphocytic leukemia (CLL). Most are diffuse large B-cell lymphomas (DLBCL), however in 10-15% of RS, there is transformation to Hodgkin lymphoma, termed "Hodgkin variant" (HV). In the present retrospective study we summarize the Israeli experience with HV-RS, and analyze demographic data, relevant laboratory and clinical parameters, and outcome. Patients and Methods: We collected and analyzed data from 119 patients with RS from 12 Centers in Israel during 1996-2010 and identified 16 cases with "Hodgkin's variant". Results: The median age was 58 years, and 67% were males. The median time from CLL diagnosis to development of HV was 5.9 (range=0.8-11.9) years and the median survival was 39.5 months, compared to 9 months for the cases with RS-DLBCL. Conclusion: Hodgkin variant appears to differ from DLBCL-RS and is clinically less aggressive. However, compared to de novo Hodgkin's lymphoma, HV-RS has a worse prognosis.
AB - Backround: Richter syndrome (RS) is the development of an aggressive lymphoid malignancy, in chronic lymphocytic leukemia (CLL). Most are diffuse large B-cell lymphomas (DLBCL), however in 10-15% of RS, there is transformation to Hodgkin lymphoma, termed "Hodgkin variant" (HV). In the present retrospective study we summarize the Israeli experience with HV-RS, and analyze demographic data, relevant laboratory and clinical parameters, and outcome. Patients and Methods: We collected and analyzed data from 119 patients with RS from 12 Centers in Israel during 1996-2010 and identified 16 cases with "Hodgkin's variant". Results: The median age was 58 years, and 67% were males. The median time from CLL diagnosis to development of HV was 5.9 (range=0.8-11.9) years and the median survival was 39.5 months, compared to 9 months for the cases with RS-DLBCL. Conclusion: Hodgkin variant appears to differ from DLBCL-RS and is clinically less aggressive. However, compared to de novo Hodgkin's lymphoma, HV-RS has a worse prognosis.
KW - Chronic lymphocytic leukemia
KW - CLL.
KW - Hodgkin's lymphoma
KW - Hodgkin's variant
KW - Richter syndrome
KW - Richter transformation
UR - http://www.scopus.com/inward/record.url?scp=84897064002&partnerID=8YFLogxK
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 24511013
AN - SCOPUS:84897064002
SN - 0250-7005
VL - 34
SP - 785
EP - 790
JO - Anticancer Research
JF - Anticancer Research
IS - 2
ER -