HLA genes in the Chuvashian population from European Russia: Admixture of Central European and Mediterranean populations

Antonio Arnaiz-Villena, Jorge Martinez-Laso, Juan Moscoso, Gregory Livshits, Jorge Zamora, Eduardo Gomez-Casado, Carlos Silvera-Redondo, Kristin Melvin, Michael H. Crawford

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

HLA alleles have been determined for the first time in individuals from the Chuvashian population by DNA typing and sequencing. HLA-A, -B, -DR, and -DQ allele frequencies and extended haplotypes have also been determined, and the results compared to those for Central Europeans, Siberians and other Asians, Caucasians, Middle Easterners, and Mediterranean peoples. Genetic distances, neighbor-joining dendrograms, and correspondence analysis have been performed. Present-day Chuvash speak an Altaic-Turkic language and are genetically related to Caucasians (Georgians), Mediterraneans, and Middle Easterners, and not only to Central or Northern Europeans; Chuvash contain little indications of Central Asian-Altaic gene flow. Thus, present-day Chuvash who speak an Altaic-Turkic language are probably more closely related to ancient Mesopotamian-Hittites and northern European populations than to central Asia-Altaic people.

Original languageEnglish
Pages (from-to)375-392
Number of pages18
JournalHuman Biology
Volume75
Issue number3
DOIs
StatePublished - Jun 2003
Externally publishedYes

Keywords

  • Bulgarians
  • Bulgars
  • Central Europe
  • Chuvash
  • HLA
  • Macedonians
  • Mediterraneans
  • Na-dene
  • Russians
  • Siberians

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