High b value q-space-analyzed diffusion MRI in vascular dementia: A preliminary study

Y. Assaf, O. Mayzel-Oreg, A. Gigi, D. Ben-Bashat, M. Mordohovitch, R. Verchovsky, I. I. Reider-Groswasser, T. Hendler, M. Graif, Y. Cohen, A. D. Korczyn

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


High b value diffusion weighted magnetic resonance imaging (high-b DWI) was used to characterize white matter changes in the brain of patients with vascular dementia (VaD). Hyperintense white matter areas detected by T2-weighted magnetic resonance imaging (MRI) represent lesions, also termed leukoaraiosis that are very common in VaD as well as in other types of dementia. Therefore, the role of white matter changes in the cognitive and memory decline that occurs in VaD patients is still under debate. High-b DWI, analyzed using the q-space approach, is a more sensitive MRI method for detection of white matter changes. High-b DWI revealed massive white matter loss in VaD patients that surpassed the boundaries of T2 hyperintensities. This technique, therefore, might serve as a better indication for the extensive nerve fiber loss in the white matter that is caused by vascular disease.

Original languageEnglish
Pages (from-to)235-239
Number of pages5
JournalJournal of the Neurological Sciences
StatePublished - 15 Nov 2002
Externally publishedYes


  • Brain imaging
  • Diffusion
  • Diffusion-weighted imaging
  • MRI
  • Vascular dementia
  • q-space


Dive into the research topics of 'High b value q-space-analyzed diffusion MRI in vascular dementia: A preliminary study'. Together they form a unique fingerprint.

Cite this