TY - JOUR
T1 - Hierarchical morphological design of immunoassay technology
AU - Levin, Mark Sh
AU - Firer, Michael A.
PY - 2005/3
Y1 - 2005/3
N2 - The paper describes a hierarchical design approach to an immunoassay. A morphology for an immunoassay technology is considered as a basis to generate system versions. A 5-stage technology is analyzed. The problem is: Find the best composite version for each stage while taking into account requirements (criteria) at each stage and compatibility between selected design alternatives at different stages. Hierarchical solving procedure consists of two parts: (a) multicriteria ranking of alternative versions at each stage (e.g., selection of Pareto-effective local decisions), (b) composition of the selected versions into a parallel-series composite system (technology). A realistic numerical example illustrates the approach.
AB - The paper describes a hierarchical design approach to an immunoassay. A morphology for an immunoassay technology is considered as a basis to generate system versions. A 5-stage technology is analyzed. The problem is: Find the best composite version for each stage while taking into account requirements (criteria) at each stage and compatibility between selected design alternatives at different stages. Hierarchical solving procedure consists of two parts: (a) multicriteria ranking of alternative versions at each stage (e.g., selection of Pareto-effective local decisions), (b) composition of the selected versions into a parallel-series composite system (technology). A realistic numerical example illustrates the approach.
KW - Biotechnology
KW - Combinatorial engineering
KW - Combinatorial optimization
KW - Immunoassay
KW - Morphological analysis
KW - Multicriteria optimization
UR - http://www.scopus.com/inward/record.url?scp=9944262894&partnerID=8YFLogxK
U2 - 10.1016/j.compbiomed.2003.11.005
DO - 10.1016/j.compbiomed.2003.11.005
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C2 - 15582630
AN - SCOPUS:9944262894
SN - 0010-4825
VL - 35
SP - 229
EP - 245
JO - Computers in Biology and Medicine
JF - Computers in Biology and Medicine
IS - 3
ER -