TY - JOUR
T1 - Hidradenitis suppurativa and schizophrenia
T2 - a nationwide cohort study
AU - Tzur Bitan, D.
AU - Berzin, D.
AU - Cohen, A. D.
N1 - Publisher Copyright:
© 2019 European Academy of Dermatology and Venereology
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Background: Hidradenitis suppurativa (HS) is a chronic, debilitating, dermatological disease that causes substantial psychosocial impediments with increased suicidal risk. Yet data on psychiatric comorbidity in HS have not been sufficiently elucidated in population-based studies. The current study sought to investigate the association between HS and schizophrenia, a major psychiatric disease, in a nationwide population-based study in Israel. Methods: Data mining was performed on the database of Clalit Health Services (CHS), the largest managed healthcare company in Israel. Patients diagnosed with HS (n = 4191) were examined and compared to age- and sex-matched controls (n = 20 941). The association between HS and schizophrenia was assessed via multivariate binary logistic regression, adjusting for demographic factors and smoking status. Results: The analysis revealed a tenfold increase in the prevalence of schizophrenia in HS patients compared to controls (1.4% and 0.4%, respectively, P < 0.001). In multivariate analysis, HS was found to be associated with schizophrenia (OR 1.44, 95% CI 1.01–2.07, P < 0.05). Conclusions: Hidradenitis suppurativa is associated with schizophrenia. Screening for severe mental illness during the assessment of patients with HS is of great importance, as comorbid psychiatric disorders may affect treatment outcomes.
AB - Background: Hidradenitis suppurativa (HS) is a chronic, debilitating, dermatological disease that causes substantial psychosocial impediments with increased suicidal risk. Yet data on psychiatric comorbidity in HS have not been sufficiently elucidated in population-based studies. The current study sought to investigate the association between HS and schizophrenia, a major psychiatric disease, in a nationwide population-based study in Israel. Methods: Data mining was performed on the database of Clalit Health Services (CHS), the largest managed healthcare company in Israel. Patients diagnosed with HS (n = 4191) were examined and compared to age- and sex-matched controls (n = 20 941). The association between HS and schizophrenia was assessed via multivariate binary logistic regression, adjusting for demographic factors and smoking status. Results: The analysis revealed a tenfold increase in the prevalence of schizophrenia in HS patients compared to controls (1.4% and 0.4%, respectively, P < 0.001). In multivariate analysis, HS was found to be associated with schizophrenia (OR 1.44, 95% CI 1.01–2.07, P < 0.05). Conclusions: Hidradenitis suppurativa is associated with schizophrenia. Screening for severe mental illness during the assessment of patients with HS is of great importance, as comorbid psychiatric disorders may affect treatment outcomes.
UR - http://www.scopus.com/inward/record.url?scp=85074848621&partnerID=8YFLogxK
U2 - 10.1111/jdv.15997
DO - 10.1111/jdv.15997
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 31587377
AN - SCOPUS:85074848621
SN - 0926-9959
VL - 34
SP - 574
EP - 579
JO - Journal of the European Academy of Dermatology and Venereology
JF - Journal of the European Academy of Dermatology and Venereology
IS - 3
ER -