TY - JOUR
T1 - Hidradenitis suppurativa and atopic dermatitis
T2 - A 2-way association
AU - Sherman, Shany
AU - Kridin, Khalaf
AU - Bitan, Dana Tzur
AU - Leshem, Yael Anne
AU - Hodak, Emmilia
AU - Cohen, Arnon Dov
N1 - Publisher Copyright:
© 2020 American Academy of Dermatology, Inc.
PY - 2021/12
Y1 - 2021/12
N2 - Background: The coexistence of hidradenitis suppurativa (HS) and atopic dermatitis (AD) had been reported but, to our knowledge, was not investigated in controlled studies. Objective: To evaluate the bidirectional association between HS and AD. Methods: A population-based retrospective cohort study was conducted to compare the incidence rate of AD among patients with HS (n = 6779) and age-, sex-, and ethnicity-matched control individuals (n = 33,260). Adjusted hazard ratios (HRs) and adjusted odds ratios were estimated. Results: The incidence of AD was 2.51 (95% confidence interval [CI], 2.07-3.02) and 1.24 (95% CI, 1.10-1.40) per 1000 person-years among patients with HS and control individuals, respectively. Patients with HS were twice as likely to develop AD as control individuals (HR, 2.06; 95% CI, 1.64-2.58). Furthermore, the prevalence of pre-existing AD was higher in patients with HS than in control individuals (2.5% vs 1.8%, respectively; P < .001). A history of AD was associated with a 40% increase in the odds of HS (odds ratio, 1.41; 95% CI, 1.19-1.67). Relative to patients with isolated HS, those with a dual diagnosis of HS and AD were younger and had a female predominance, lower prevalence of smoking, and lower body mass index. Limitations: Retrospective data collection. Conclusions: A bidirectional association between HS and AD was observed. Dermatologists should be aware of this association.
AB - Background: The coexistence of hidradenitis suppurativa (HS) and atopic dermatitis (AD) had been reported but, to our knowledge, was not investigated in controlled studies. Objective: To evaluate the bidirectional association between HS and AD. Methods: A population-based retrospective cohort study was conducted to compare the incidence rate of AD among patients with HS (n = 6779) and age-, sex-, and ethnicity-matched control individuals (n = 33,260). Adjusted hazard ratios (HRs) and adjusted odds ratios were estimated. Results: The incidence of AD was 2.51 (95% confidence interval [CI], 2.07-3.02) and 1.24 (95% CI, 1.10-1.40) per 1000 person-years among patients with HS and control individuals, respectively. Patients with HS were twice as likely to develop AD as control individuals (HR, 2.06; 95% CI, 1.64-2.58). Furthermore, the prevalence of pre-existing AD was higher in patients with HS than in control individuals (2.5% vs 1.8%, respectively; P < .001). A history of AD was associated with a 40% increase in the odds of HS (odds ratio, 1.41; 95% CI, 1.19-1.67). Relative to patients with isolated HS, those with a dual diagnosis of HS and AD were younger and had a female predominance, lower prevalence of smoking, and lower body mass index. Limitations: Retrospective data collection. Conclusions: A bidirectional association between HS and AD was observed. Dermatologists should be aware of this association.
KW - atopic dermatitis (AD)
KW - bidirectional association
KW - case-control study
KW - cohort study
KW - hidradenitis suppurativa (HS)
UR - http://www.scopus.com/inward/record.url?scp=85101020230&partnerID=8YFLogxK
U2 - 10.1016/j.jaad.2020.12.051
DO - 10.1016/j.jaad.2020.12.051
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C2 - 33378660
AN - SCOPUS:85101020230
SN - 0190-9622
VL - 85
SP - 1473
EP - 1479
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 6
ER -