Hemocompatibility study of a bacterial cellulose/polyvinyl alcohol nanocomposite

Alexandre F. Leitão; Swati Gupta; João Pedro Silva; Ilya Reviakine; Miguel Gama

doi:10.1016/j.colsurfb.2013.06.031

Hemocompatibility study of a bacterial cellulose/polyvinyl alcohol nanocomposite

Alexandre F. Leitão
, Swati Gupta
, João Pedro Silva
, Ilya Reviakine
, Miguel Gama

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

Bacterial cellulose (BC) has been suggested to be a suitable biomaterial for the development of cardiovascular grafts. The combination of BC with polyvinyl alcohol (PVA) results in nanocomposites with improved properties. Surprisingly, there are very few studies on the BC-blood interaction. This is the focus of this paper. We present the first thorough assessment of the hemocompatibility of the BC/PVA nanocomposite. Whole blood clotting time, plasma recalcification, Factor XII activation, platelet adhesion and activation, hemolytic index and complement activation are all determined. The platelet activation profiles on BC and BC/PVA surfaces are comprehensively characterized. BC and BC/PVA outperformed ePTFE - used as a point of comparison - thus evidencing their suitability for cardiovascular applications.

Original language	English
Pages (from-to)	493-502
Number of pages	10
Journal	Colloids and Surfaces B: Biointerfaces
Volume	111
DOIs	https://doi.org/10.1016/j.colsurfb.2013.06.031
State	Published - 1 Nov 2013
Externally published	Yes

Keywords

Bacterial cellulose
Biocompatibility
Biomaterials
Hemocompatibility
Platelets
Polyvinyl alcohol

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10.1016/j.colsurfb.2013.06.031

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title = "Hemocompatibility study of a bacterial cellulose/polyvinyl alcohol nanocomposite",

abstract = "Bacterial cellulose (BC) has been suggested to be a suitable biomaterial for the development of cardiovascular grafts. The combination of BC with polyvinyl alcohol (PVA) results in nanocomposites with improved properties. Surprisingly, there are very few studies on the BC-blood interaction. This is the focus of this paper. We present the first thorough assessment of the hemocompatibility of the BC/PVA nanocomposite. Whole blood clotting time, plasma recalcification, Factor XII activation, platelet adhesion and activation, hemolytic index and complement activation are all determined. The platelet activation profiles on BC and BC/PVA surfaces are comprehensively characterized. BC and BC/PVA outperformed ePTFE - used as a point of comparison - thus evidencing their suitability for cardiovascular applications.",

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AU - Leitão, Alexandre F.

AU - Gupta, Swati

AU - Silva, João Pedro

AU - Reviakine, Ilya

AU - Gama, Miguel

PY - 2013/11/1

Y1 - 2013/11/1

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AB - Bacterial cellulose (BC) has been suggested to be a suitable biomaterial for the development of cardiovascular grafts. The combination of BC with polyvinyl alcohol (PVA) results in nanocomposites with improved properties. Surprisingly, there are very few studies on the BC-blood interaction. This is the focus of this paper. We present the first thorough assessment of the hemocompatibility of the BC/PVA nanocomposite. Whole blood clotting time, plasma recalcification, Factor XII activation, platelet adhesion and activation, hemolytic index and complement activation are all determined. The platelet activation profiles on BC and BC/PVA surfaces are comprehensively characterized. BC and BC/PVA outperformed ePTFE - used as a point of comparison - thus evidencing their suitability for cardiovascular applications.

KW - Bacterial cellulose

KW - Biocompatibility

KW - Biomaterials

KW - Hemocompatibility

KW - Platelets

KW - Polyvinyl alcohol

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ER -

Hemocompatibility study of a bacterial cellulose/polyvinyl alcohol nanocomposite

Abstract

Keywords

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