TY - JOUR
T1 - Helicobacter pylori infection is positively associated with an increased BMI, irrespective of socioeconomic status and other confounders
T2 - A cohort study
AU - Suki, Mohamad
AU - Leibovici Weissman, Yaara
AU - Boltin, Doron
AU - Itskoviz, David
AU - Tsadok Perets, Tsachi
AU - Comaneshter, Doron
AU - Cohen, Arnon
AU - Niv, Yaron
AU - Dotan, Iris
AU - Leibovitzh, Haim
AU - Levi, Zohar
N1 - Publisher Copyright:
Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2018
Y1 - 2018
N2 - Background Data on the association of Helicobacter pylori infection and BMI are conflicting. The fact that both H. pylori infection and BMI are associated with low socioeconomic status (SES) makes this relationship difficult to characterize. Materials and methods We aimed to evaluate the association between BMI and H. pylori infection after adjusting for multiple covariates. We analyzed a cohort of 235 107 individuals aged 18 years or older, who performed a 13 C urease breath test (13 C-UBT), from 2007 to 2014. Data on BMI, age, sex, SES, ethnicity, and medications were extracted from a nationwide population-based database. BMIs were classified according to the WHO recommendations: underweight (<18.5 kg/m 2), normal weight (18.5-24.9 kg/m 2), overweight (25-29.9 kg/m 2), obese class I (30-34.9 kg/m 2), and obese class II or more (>35 kg/m 2). Study results The positivity rate for H. pylori among underweight, normal weight, overweight, and obese class I and class II or more was 55.6, 58.5, 63.0, 64.5, and 65.5%, respectively (P<0.001, P linear trend 0.007). The association between BMI and H. pylori infection was significant across all SES, sex, ethnicity, and age categories. After adjusting for age, sex, ethnicity, and SES, being overweight and obese class I and class II or more were associated significantly with H. pylori positivity: odds ratio 1.13 [95% confidence interval (CI): 1.11-1.15], 1.14 (95% CI: 1.11-1.17), and 1.15 (95% CI: 1.11-1.19), respectively, P value less than 0.001 for all. Conclusion Among individuals who were referred to a 13 C-UBT by primary care physician, after adjusting for multiple covariates including SES, we found a positive association between H. pylori infection and an increased BMI.
AB - Background Data on the association of Helicobacter pylori infection and BMI are conflicting. The fact that both H. pylori infection and BMI are associated with low socioeconomic status (SES) makes this relationship difficult to characterize. Materials and methods We aimed to evaluate the association between BMI and H. pylori infection after adjusting for multiple covariates. We analyzed a cohort of 235 107 individuals aged 18 years or older, who performed a 13 C urease breath test (13 C-UBT), from 2007 to 2014. Data on BMI, age, sex, SES, ethnicity, and medications were extracted from a nationwide population-based database. BMIs were classified according to the WHO recommendations: underweight (<18.5 kg/m 2), normal weight (18.5-24.9 kg/m 2), overweight (25-29.9 kg/m 2), obese class I (30-34.9 kg/m 2), and obese class II or more (>35 kg/m 2). Study results The positivity rate for H. pylori among underweight, normal weight, overweight, and obese class I and class II or more was 55.6, 58.5, 63.0, 64.5, and 65.5%, respectively (P<0.001, P linear trend 0.007). The association between BMI and H. pylori infection was significant across all SES, sex, ethnicity, and age categories. After adjusting for age, sex, ethnicity, and SES, being overweight and obese class I and class II or more were associated significantly with H. pylori positivity: odds ratio 1.13 [95% confidence interval (CI): 1.11-1.15], 1.14 (95% CI: 1.11-1.17), and 1.15 (95% CI: 1.11-1.19), respectively, P value less than 0.001 for all. Conclusion Among individuals who were referred to a 13 C-UBT by primary care physician, after adjusting for multiple covariates including SES, we found a positive association between H. pylori infection and an increased BMI.
KW - BMI
KW - Helicobacter pylori
KW - obesity
UR - http://www.scopus.com/inward/record.url?scp=85042361975&partnerID=8YFLogxK
U2 - 10.1097/MEG.0000000000001014
DO - 10.1097/MEG.0000000000001014
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 29120907
AN - SCOPUS:85042361975
SN - 0954-691X
VL - 30
SP - 143
EP - 148
JO - European Journal of Gastroenterology and Hepatology
JF - European Journal of Gastroenterology and Hepatology
IS - 2
ER -