Granulation tissue concentrations of ofloxacin after oral administration in invasive external otitis

M. Z. Himmelfarb; D. Zikk; Y. Rapoport; C. Redianu; I. Shalit

doi:10.1007/BF02540111

Granulation tissue concentrations of ofloxacin after oral administration in invasive external otitis

M. Z. Himmelfarb, D. Zikk, Y. Rapoport, C. Redianu, I. Shalit

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4 Scopus citations

Abstract

Following the fourth dose of 400 mg orally administered ofloxacin, simultaneous external ear canal granulation tissue and serum ofloxacin concentrations were estimated in 15 patients with invasive external otitis. The granulation tissue concentration was 2.2 (range 1.17-4.34) times higher than the serum concentration and 3.73 (range 1.95-11.00) times higher than the MIC₉₀ of ofloxacin against Pseudomonas aeruginosa.

Original language	English
Pages (from-to)	S15-S17
Journal	European Archives of Oto-Rhino-Laryngology
Volume	250
Issue number	1 Supplement
DOIs	https://doi.org/10.1007/BF02540111
State	Published - Mar 1993
Externally published	Yes

Keywords

Antibiotic tissue concentration
Fluoroquinolones
Invasive otitis externa
Ofloxacin
Pseudomonas aeruginosa

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10.1007/BF02540111

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abstract = "Following the fourth dose of 400 mg orally administered ofloxacin, simultaneous external ear canal granulation tissue and serum ofloxacin concentrations were estimated in 15 patients with invasive external otitis. The granulation tissue concentration was 2.2 (range 1.17-4.34) times higher than the serum concentration and 3.73 (range 1.95-11.00) times higher than the MIC90 of ofloxacin against Pseudomonas aeruginosa.",

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AU - Zikk, D.

AU - Rapoport, Y.

AU - Redianu, C.

AU - Shalit, I.

PY - 1993/3

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AB - Following the fourth dose of 400 mg orally administered ofloxacin, simultaneous external ear canal granulation tissue and serum ofloxacin concentrations were estimated in 15 patients with invasive external otitis. The granulation tissue concentration was 2.2 (range 1.17-4.34) times higher than the serum concentration and 3.73 (range 1.95-11.00) times higher than the MIC90 of ofloxacin against Pseudomonas aeruginosa.

KW - Antibiotic tissue concentration

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KW - Invasive otitis externa

KW - Ofloxacin

KW - Pseudomonas aeruginosa

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IS - 1 Supplement

ER -

Granulation tissue concentrations of ofloxacin after oral administration in invasive external otitis

Abstract

Keywords

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