Genetic Predisposition to Hodgkin's Disease

Ofer Shpilberg, Avner Shahar, Thomas M. Mack, Wendy Cozen

Research output: Contribution to journalLetterpeer-review


To the Editor: From their study of Hodgkin's disease in monozygotic and dizygotic twins, Mack et al. (Feb. 16 issue)1 concluded that genetic susceptibility underlies certain subtypes of Hodgkin's disease. We have studied the familial aggregation of hematologic neoplasms among 4061 relatives of 189 patients with any kind of hematologic neoplasm.2 Fifty-six of the relatives (1.4 percent) had a hematologic neoplasm, with a calculated odds ratio of 3.62 (95 percent confidence interval, 1.44 to 9.07; P<0.01) as compared with two control groups and after adjustment for age, sex, ethnic group, number of relatives in the family, and degree of familial.

Original languageEnglish
Pages (from-to)64-65
Number of pages2
JournalNew England Journal of Medicine
Issue number1
StatePublished - 6 Jul 1995
Externally publishedYes


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