TY - JOUR
T1 - Genetic Predisposition to Hodgkin's Disease
AU - Shpilberg, Ofer
AU - Shahar, Avner
AU - Mack, Thomas M.
AU - Cozen, Wendy
PY - 1995/7/6
Y1 - 1995/7/6
N2 - To the Editor: From their study of Hodgkin's disease in monozygotic and dizygotic twins, Mack et al. (Feb. 16 issue)1 concluded that genetic susceptibility underlies certain subtypes of Hodgkin's disease. We have studied the familial aggregation of hematologic neoplasms among 4061 relatives of 189 patients with any kind of hematologic neoplasm.2 Fifty-six of the relatives (1.4 percent) had a hematologic neoplasm, with a calculated odds ratio of 3.62 (95 percent confidence interval, 1.44 to 9.07; P<0.01) as compared with two control groups and after adjustment for age, sex, ethnic group, number of relatives in the family, and degree of familial.
AB - To the Editor: From their study of Hodgkin's disease in monozygotic and dizygotic twins, Mack et al. (Feb. 16 issue)1 concluded that genetic susceptibility underlies certain subtypes of Hodgkin's disease. We have studied the familial aggregation of hematologic neoplasms among 4061 relatives of 189 patients with any kind of hematologic neoplasm.2 Fifty-six of the relatives (1.4 percent) had a hematologic neoplasm, with a calculated odds ratio of 3.62 (95 percent confidence interval, 1.44 to 9.07; P<0.01) as compared with two control groups and after adjustment for age, sex, ethnic group, number of relatives in the family, and degree of familial.
UR - http://www.scopus.com/inward/record.url?scp=0029012488&partnerID=8YFLogxK
U2 - 10.1056/NEJM199507063330116
DO - 10.1056/NEJM199507063330116
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.letter???
C2 - 7777004
AN - SCOPUS:0029012488
SN - 0028-4793
VL - 333
SP - 64
EP - 65
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 1
ER -