Generalized seizures following topical lidocaine administration during circumcision: Establishing causation

Massoud Rezvani; Yaron Finkelstein; Zul Verjee; Craig Railton; Gideon Koren

doi:10.2165/00148581-200709020-00006

Generalized seizures following topical lidocaine administration during circumcision: Establishing causation

Massoud Rezvani, Yaron Finkelstein, Zul Verjee, Craig Railton, Gideon Koren

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We report a case of neonatal seizures after lidocaine administration for circumcision. A 3-month-old male infant received an overdose as evidenced by toxic lidocaine levels and developed generalized seizures shortly after. Back extrapolation of the serum lidocaine concentration to time zero was used to determine the administered dose. The Naranjo scale was used to determine causation; probable causation was defined. Particular care must be taken to administer an appropriate dose of local anesthetics in infants to avoid life-threatening seizures.

Original language	English
Pages (from-to)	125-127
Number of pages	3
Journal	Paediatric Drugs
Volume	9
Issue number	2
DOIs	https://doi.org/10.2165/00148581-200709020-00006
State	Published - 2007
Externally published	Yes

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title = "Generalized seizures following topical lidocaine administration during circumcision: Establishing causation",

abstract = "We report a case of neonatal seizures after lidocaine administration for circumcision. A 3-month-old male infant received an overdose as evidenced by toxic lidocaine levels and developed generalized seizures shortly after. Back extrapolation of the serum lidocaine concentration to time zero was used to determine the administered dose. The Naranjo scale was used to determine causation; probable causation was defined. Particular care must be taken to administer an appropriate dose of local anesthetics in infants to avoid life-threatening seizures.",

author = "Massoud Rezvani and Yaron Finkelstein and Zul Verjee and Craig Railton and Gideon Koren",

note = "Funding Information: Dr Finkelstein is supported by a fellowship of The Research Training Center, The Hospital for Sick Children, Toronto, ON, Canada. Dr Koren holds the Ivey chair in Molecular Toxicology, University of Western Ontario, London, ON, Canada.",

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AU - Railton, Craig

AU - Koren, Gideon

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Generalized seizures following topical lidocaine administration during circumcision: Establishing causation

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