Functionalized polysulfone as a novel and useful carrier for immunization and antibody detection

Rina Arad-Yellin, Michael Firer, Nava Kahana, Bernard S. Green

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The well-known polymer, polysulfone (PS), was used, via its carboxylated derivative, as a carrier vehicle for low-molecular weight substances (haptens). The synthesis and characterization of conjugates of PS-CO2H (1) coupled to a relatively non-immunogenic aliphatic hapten (2) or an aromatic hapten (3) and various intermediates in their syntheses, are reported. Immunization with 1, 2, and 3 afforded anti-hapten antibodies and, interestingly, provided evidence for significant adjuvant activity by 1 and related substances. Further studies are called for in order to understand the mechanism of action and correlate immune activity with structure, but these initial results indicate the intriguing possibility of novel immunization methods, free of conventional, toxic adjuvants.

Original languageEnglish
Pages (from-to)5-16
Number of pages12
JournalReactive and Functional Polymers
Issue number1-3
StatePublished - Jan 2003


  • Adjuvant
  • Functionalized polymer
  • Hapten-polymer immunogen
  • Modified polysulfone
  • Polysulfone carboxylic acid


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