TY - JOUR
T1 - Functional connectivity analysis of the neural circuits of opiate craving
T2 - "more" rather than "different"?
AU - Daglish, Mark R.C.
AU - Weinstein, Aviv
AU - Malizia, Andrea L.
AU - Wilson, Susan
AU - Melichar, Jan K.
AU - Lingford-Hughes, Anne
AU - Myles, Judith S.
AU - Grasby, Paul
AU - Nutt, David J.
N1 - Funding Information:
This work was, in part, funded by an MRC Programme Grant. The authors thank the staff of the drug treatment agencies for help in recruiting the subjects for this study, in particular Steve Barnes, Dr. Colin Brewer, and Dr. Simon Britten. A.L.M. was a Wellcome Training Fellow.
PY - 2003/12
Y1 - 2003/12
N2 - We investigated the functional connectivity of brain regions activated during opiate craving. Previously we used recorded autobiographical scripts to induce opiate craving in 12 abstinent opiate-dependent subjects while they were undergoing positron emission tomography (PET) scanning using the regional cerebral blood flow (rCBF) tracer H215O. SPM99 was used to examine the connectivity patterns associated with the primary brain regions activated in response to drug-craving memories (anterior cingulate, AC) and correlated with opiate craving (orbitofrontal cortex, OFC). Two separate connectivity patterns were identified associated with the OFC and AC regions. The AC region was associated with activity in the left temporal region. The left OFC region activity correlated with activity in the right OFC, and left parietal and posterior insular regions. There was also a positive association with the hippocampus and brainstem. Both the AC and OFC regions showed a negative association with posterior visual areas. We suggest that the patterns of functional connectivity reflect the ability of drug-related stimuli to activate attentional and memory circuits to a greater degree than non-drug-related stimuli. This argues that neural circuits of dependence and craving are not specific "craving" or "addiction" brain regions but are "normal" circuits activated to a greater degree.
AB - We investigated the functional connectivity of brain regions activated during opiate craving. Previously we used recorded autobiographical scripts to induce opiate craving in 12 abstinent opiate-dependent subjects while they were undergoing positron emission tomography (PET) scanning using the regional cerebral blood flow (rCBF) tracer H215O. SPM99 was used to examine the connectivity patterns associated with the primary brain regions activated in response to drug-craving memories (anterior cingulate, AC) and correlated with opiate craving (orbitofrontal cortex, OFC). Two separate connectivity patterns were identified associated with the OFC and AC regions. The AC region was associated with activity in the left temporal region. The left OFC region activity correlated with activity in the right OFC, and left parietal and posterior insular regions. There was also a positive association with the hippocampus and brainstem. Both the AC and OFC regions showed a negative association with posterior visual areas. We suggest that the patterns of functional connectivity reflect the ability of drug-related stimuli to activate attentional and memory circuits to a greater degree than non-drug-related stimuli. This argues that neural circuits of dependence and craving are not specific "craving" or "addiction" brain regions but are "normal" circuits activated to a greater degree.
UR - http://www.scopus.com/inward/record.url?scp=0346995474&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2003.07.025
DO - 10.1016/j.neuroimage.2003.07.025
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C2 - 14683702
AN - SCOPUS:0346995474
SN - 1053-8119
VL - 20
SP - 1964
EP - 1970
JO - NeuroImage
JF - NeuroImage
IS - 4
ER -