TY - JOUR
T1 - Fractal and textural imaging identify new subgroups of patients with colorectal cancer based on biophysical properties of the cancer cells
AU - Karri, Sirish
AU - Aviel-Ronen, Sarit
AU - Firer, Michael A.
N1 - Publisher Copyright:
© 2022 Elsevier GmbH
PY - 2022/10
Y1 - 2022/10
N2 - Colorectal cancer (CRC) can been sub-divided, based on the generation of tertiary lymphoid structures (TLS), into CRC with a Crohn's like lymphoid reaction (CLR) representing de novo formation of TLSs or CRC lacking TLSs that show Diffuse Inflammatory infiltration (DII). The association between TLS, early treatment initiation and longer survival highlights the need for deeper patient stratification that could lead to more targeted therapies. We hypothesized that such stratification might be achieved by using digital image analyses. Here we retrospectively analyzed 35 CRC patient samples classified as CLR or DII by digital analysis, focusing on the parameters Fractal dimension, Lacunarity and the textural features Angular second momentum, Correlation, Inverse difference momentum and Entropy. Significant differences in the grades of these parameters between the two patient groups provided preliminary data that additional biophysical information can divide CRC into at least 3 subgroups which encompass CLR and DII. Additional studies are needed to test if this sub-classification aids in the selection of targeted therapy for patients with CRC.
AB - Colorectal cancer (CRC) can been sub-divided, based on the generation of tertiary lymphoid structures (TLS), into CRC with a Crohn's like lymphoid reaction (CLR) representing de novo formation of TLSs or CRC lacking TLSs that show Diffuse Inflammatory infiltration (DII). The association between TLS, early treatment initiation and longer survival highlights the need for deeper patient stratification that could lead to more targeted therapies. We hypothesized that such stratification might be achieved by using digital image analyses. Here we retrospectively analyzed 35 CRC patient samples classified as CLR or DII by digital analysis, focusing on the parameters Fractal dimension, Lacunarity and the textural features Angular second momentum, Correlation, Inverse difference momentum and Entropy. Significant differences in the grades of these parameters between the two patient groups provided preliminary data that additional biophysical information can divide CRC into at least 3 subgroups which encompass CLR and DII. Additional studies are needed to test if this sub-classification aids in the selection of targeted therapy for patients with CRC.
KW - Colorectal cancer
KW - Digital image analysis
KW - Fractal dimension
KW - Texture analysis
UR - http://www.scopus.com/inward/record.url?scp=85137073529&partnerID=8YFLogxK
U2 - 10.1016/j.prp.2022.154040
DO - 10.1016/j.prp.2022.154040
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AN - SCOPUS:85137073529
SN - 0344-0338
VL - 238
JO - Pathology Research and Practice
JF - Pathology Research and Practice
M1 - 154040
ER -