First report of a persistent oropharyngeal infection of type 2 vaccine-derived poliovirus (iVDPV2) in a primary immune deficient (PID) patient after eradication of wild type 2 poliovirus

Merav Weil; Galia Rahav; Raz Somech; Tali Stauber; Jacqueline Alfandari; Leah Weiss; Ilana Silberstein; Victoria Indenbaum; Itay Bar Or; Ella Mendelson; Danit Sofer; Lester M. Shulman

doi:10.1016/j.ijid.2019.03.037

First report of a persistent oropharyngeal infection of type 2 vaccine-derived poliovirus (iVDPV2) in a primary immune deficient (PID) patient after eradication of wild type 2 poliovirus

Merav Weil, Galia Rahav, Raz Somech, Tali Stauber, Jacqueline Alfandari, Leah Weiss, Ilana Silberstein, Victoria Indenbaum, Itay Bar Or, Ella Mendelson, Danit Sofer, Lester M. Shulman

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

This is the first report of persistent oropharyngeal mucosal infection with type 2 poliovirus (iVDPV2) in a primary immune deficient patient (PID) after wild type 2 poliovirus eradication. The iVDPV2 also established persistence in the gut. iVDPV2 at both loci evolved independently. Persistent oral infections present a potential risk for oral-oral as well as fecal-oral poliovirus transmission during transition to a poliovirus 2-free world.

Original language	English
Pages (from-to)	40-43
Number of pages	4
Journal	International Journal of Infectious Diseases
Volume	83
DOIs	https://doi.org/10.1016/j.ijid.2019.03.037
State	Published - Jun 2019
Externally published	Yes

Keywords

Contact isolation
Droplet isolation
Oropharyngeal mucosa
Primary immune deficiency (PID)
Stools
Type 2 vaccine-derived poliovirus (iVDPV2)

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10.1016/j.ijid.2019.03.037

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Weil, M., Rahav, G., Somech, R., Stauber, T., Alfandari, J., Weiss, L., Silberstein, I., Indenbaum, V., Or, I. B., Mendelson, E., Sofer, D., & Shulman, L. M. (2019). First report of a persistent oropharyngeal infection of type 2 vaccine-derived poliovirus (iVDPV2) in a primary immune deficient (PID) patient after eradication of wild type 2 poliovirus. International Journal of Infectious Diseases, 83, 40-43. https://doi.org/10.1016/j.ijid.2019.03.037

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title = "First report of a persistent oropharyngeal infection of type 2 vaccine-derived poliovirus (iVDPV2) in a primary immune deficient (PID) patient after eradication of wild type 2 poliovirus",

abstract = "This is the first report of persistent oropharyngeal mucosal infection with type 2 poliovirus (iVDPV2) in a primary immune deficient patient (PID) after wild type 2 poliovirus eradication. The iVDPV2 also established persistence in the gut. iVDPV2 at both loci evolved independently. Persistent oral infections present a potential risk for oral-oral as well as fecal-oral poliovirus transmission during transition to a poliovirus 2-free world.",

keywords = "Contact isolation, Droplet isolation, Oropharyngeal mucosa, Primary immune deficiency (PID), Stools, Type 2 vaccine-derived poliovirus (iVDPV2)",

author = "Merav Weil and Galia Rahav and Raz Somech and Tali Stauber and Jacqueline Alfandari and Leah Weiss and Ilana Silberstein and Victoria Indenbaum and Or, {Itay Bar} and Ella Mendelson and Danit Sofer and Shulman, {Lester M.}",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = jun,

doi = "10.1016/j.ijid.2019.03.037",

language = "אנגלית",

volume = "83",

pages = "40--43",

journal = "International Journal of Infectious Diseases",

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Weil, M, Rahav, G, Somech, R, Stauber, T, Alfandari, J, Weiss, L, Silberstein, I, Indenbaum, V, Or, IB, Mendelson, E, Sofer, D & Shulman, LM 2019, 'First report of a persistent oropharyngeal infection of type 2 vaccine-derived poliovirus (iVDPV2) in a primary immune deficient (PID) patient after eradication of wild type 2 poliovirus', International Journal of Infectious Diseases, vol. 83, pp. 40-43. https://doi.org/10.1016/j.ijid.2019.03.037

First report of a persistent oropharyngeal infection of type 2 vaccine-derived poliovirus (iVDPV2) in a primary immune deficient (PID) patient after eradication of wild type 2 poliovirus. / Weil, Merav; Rahav, Galia; Somech, Raz et al.
In: International Journal of Infectious Diseases, Vol. 83, 06.2019, p. 40-43.

Research output: Contribution to journal › Article › peer-review

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T1 - First report of a persistent oropharyngeal infection of type 2 vaccine-derived poliovirus (iVDPV2) in a primary immune deficient (PID) patient after eradication of wild type 2 poliovirus

AU - Weil, Merav

AU - Rahav, Galia

AU - Somech, Raz

AU - Stauber, Tali

AU - Alfandari, Jacqueline

AU - Weiss, Leah

AU - Silberstein, Ilana

AU - Indenbaum, Victoria

AU - Or, Itay Bar

AU - Mendelson, Ella

AU - Sofer, Danit

AU - Shulman, Lester M.

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KW - Contact isolation

KW - Droplet isolation

KW - Oropharyngeal mucosa

KW - Primary immune deficiency (PID)

KW - Stools

KW - Type 2 vaccine-derived poliovirus (iVDPV2)

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ER -

First report of a persistent oropharyngeal infection of type 2 vaccine-derived poliovirus (iVDPV2) in a primary immune deficient (PID) patient after eradication of wild type 2 poliovirus

Abstract

Keywords

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