Fifteen years of APC/cyclosome: A short and impressive biography

Kobi J. Simpson-Lavy; Yifat S. Oren; Oren Feine; Julia Sajman; Tammy Listovsky; Michael Brandeis

doi:10.1042/BST0380078

Fifteen years of APC/cyclosome: A short and impressive biography

Kobi J. Simpson-Lavy, Yifat S. Oren, Oren Feine, Julia Sajman, Tammy Listovsky, Michael Brandeis

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20 Scopus citations

Abstract

The APC/C (anaphase-promoting complex/cyclosome) discovered exactly 15 years ago by Avram Heshko and Marc Kirschner is by far the most complex ubiquitin ligase discovered so far. The APC/C is composed of roughly a dozen subunits and measures a massive 1.5 MDa. This huge complex, as well as its multiple modes of regulation, boasts impressive evolutionary conservation. One of its most puzzling features is its split personality: regulation of mitotic exit events on the one hand, and its ongoing activity during G1-phase, G0-phase and in terminally differentiated cells. The present short review is intended to provide a basic description of our current understanding of the APC/C, focusing on recent findings concerning its role in G1-phase and in differentiated cells.

Original language	English
Pages (from-to)	78-82
Number of pages	5
Journal	Biochemical Society Transactions
Volume	38
Issue number	1
DOIs	https://doi.org/10.1042/BST0380078
State	Published - 2010
Externally published	Yes

Keywords

Anaphase-promoting complex/cyclosome (APC/C)
Cell cycle
Degron
Mitotic switch
Ubiquitin ligase
Ubiquitination

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10.1042/BST0380078

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Fifteen years of APC/cyclosome: A short and impressive biography

Abstract

Keywords

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