Factors associated with radiation exposure in patients with inflammatory bowel disease

Z. Levi, A. Fraser, R. Krongrad, R. Hazazi, O. Benjaminov, J. Meyerovitch, O. B. Tal, A. Choen, Y. Niv, G. Fraser

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


Background Inflammatory bowel disease (IBD) patients undergo multiple radiological evaluations. Aim To estimate total and abdominal radiation exposure from diagnostic X-ray investigations in IBD patients and the associated risk factors. Methods Patients with Crohn's disease (CD) or ulcerative colitis (UC) treated in the IBD clinic were recruited. Clinical data were extracted from patient files and radiological data were obtained from the central HMO computer data base. Results A total of 199 CD and 125 UC patients were included. The mean cumulative estimated doses (CED) for CD and UC were 21.1 ± 19.5 and 15.1 ± 20.4 millisieverts (mSv) respectively (P < 0.001). Twenty-three patients (7.1%) had an estimated CED of ≥50 mSv. In multivariate analyses, predictors of increased CED were: surgery (OR 5.68, 95% CI: 2.73-11.8, P < 0.001), CD (OR 2.56, 95% CI: 1.29-5.07, P = 0.007), prednisone use (OR 2.0, 95% CI: 1.11-3.67, P = 0.02), first year of disease (OR 6.4, 95% CI: 1.3-32, P = 0.02) and age in the upper quartile (OR 3.26, 95% CI: 1.68-6.3, P = 0.001). Conclusions Diagnosis of CD, IBD-related surgery, prednisone use, first year of diagnosis and age on the upper quartile are independent predictors of increased exposure in IBD patients. Alternative investigations which do not require radiation exposure should be considered for patients at risk for increased radiation exposure.

Original languageEnglish
Pages (from-to)1128-1136
Number of pages9
JournalAlimentary Pharmacology and Therapeutics
Issue number11-12
StatePublished - Dec 2009
Externally publishedYes


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