Facile synthesis and antitumor activity of novel N(9) methylated AHMA analogs

Boris Redko; Amnon Albeck; Gary Gellerman

doi:10.1039/c2nj40567a

Facile synthesis and antitumor activity of novel N(9) methylated AHMA analogs

Boris Redko, Amnon Albeck, Gary Gellerman

Department of Chemical Sciences

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A facile synthesis of novel antitumor N(9)-methyl-3-(9-acridinylamino)-5- hydroxymethylaniline (AHMA) derivatives is described. Boc protection of aminobenzoic acids followed by LiAlH₄ reduction yielded novel methylaminobenzyl alcohol reactants. Their interaction with 9-chloroacridine provides N(9)-methylated AHMA derivatives for biological screening. A preliminary anti-proliferative assay against seven cancer cell lines identified compounds with low μM IC₅₀ values.

Original language	English
Pages (from-to)	2188-2191
Number of pages	4
Journal	New Journal of Chemistry
Volume	36
Issue number	11
DOIs	https://doi.org/10.1039/c2nj40567a
State	Published - Nov 2012

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abstract = "A facile synthesis of novel antitumor N(9)-methyl-3-(9-acridinylamino)-5- hydroxymethylaniline (AHMA) derivatives is described. Boc protection of aminobenzoic acids followed by LiAlH4 reduction yielded novel methylaminobenzyl alcohol reactants. Their interaction with 9-chloroacridine provides N(9)-methylated AHMA derivatives for biological screening. A preliminary anti-proliferative assay against seven cancer cell lines identified compounds with low μM IC50 values.",

author = "Boris Redko and Amnon Albeck and Gary Gellerman",

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AB - A facile synthesis of novel antitumor N(9)-methyl-3-(9-acridinylamino)-5- hydroxymethylaniline (AHMA) derivatives is described. Boc protection of aminobenzoic acids followed by LiAlH4 reduction yielded novel methylaminobenzyl alcohol reactants. Their interaction with 9-chloroacridine provides N(9)-methylated AHMA derivatives for biological screening. A preliminary anti-proliferative assay against seven cancer cell lines identified compounds with low μM IC50 values.

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Facile synthesis and antitumor activity of novel N(9) methylated AHMA analogs

Abstract

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