TY - JOUR
T1 - Exposure to fluconazole and risk of congenital malformations in the offspring
T2 - A systematic review and meta-analysis
AU - Alsaad, Abdulaziz M.S.
AU - Kaplan, Yusuf C.
AU - Koren, Gideon
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Vulvovaginal candidiasis (VVC) affects up to 75% of women at least once during their lifetime, mostly during the reproductive age, and recurrence rate is about 50%. Because half of all pregnancies are unplanned and pregnant women have an increased risk of VVC recurrence, the likelihood of inadvertently being exposed to fluconazole in pregnancy is increased. Thus, we aimed to examine the risk of congenital malformations in the offspring of women exposed to fluconazole in the first trimester of pregnancy. The rate for overall malformations was 1.10 (95% CI 0.98-1.25), for heart defect was 1.29 (95% CI 1.05-1.58), for craniofacial defects was 1.25 (95% CI 0.88-1.77), and for limb/musculoskeletal defects was 0.82 (95% CI 0.59-1.13). In conclusion, the use of fluconazole in the first trimester does not appear to increase the overall risk for congennital malformations. More studies are needed to address the potential increased rate of heart defects.
AB - Vulvovaginal candidiasis (VVC) affects up to 75% of women at least once during their lifetime, mostly during the reproductive age, and recurrence rate is about 50%. Because half of all pregnancies are unplanned and pregnant women have an increased risk of VVC recurrence, the likelihood of inadvertently being exposed to fluconazole in pregnancy is increased. Thus, we aimed to examine the risk of congenital malformations in the offspring of women exposed to fluconazole in the first trimester of pregnancy. The rate for overall malformations was 1.10 (95% CI 0.98-1.25), for heart defect was 1.29 (95% CI 1.05-1.58), for craniofacial defects was 1.25 (95% CI 0.88-1.77), and for limb/musculoskeletal defects was 0.82 (95% CI 0.59-1.13). In conclusion, the use of fluconazole in the first trimester does not appear to increase the overall risk for congennital malformations. More studies are needed to address the potential increased rate of heart defects.
KW - Cardiovascular defects
KW - Fluconazole
KW - Infants
KW - Pregnancy
KW - Teratogenicity
KW - Vulvovaginal candidiasis
UR - http://www.scopus.com/inward/record.url?scp=84924311183&partnerID=8YFLogxK
U2 - 10.1016/j.reprotox.2015.02.009
DO - 10.1016/j.reprotox.2015.02.009
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C2 - 25724389
AN - SCOPUS:84924311183
SN - 0890-6238
VL - 52
SP - 78
EP - 82
JO - Reproductive Toxicology
JF - Reproductive Toxicology
ER -