Exposure to fluconazole and risk of congenital malformations in the offspring: A systematic review and meta-analysis

Abdulaziz M.S. Alsaad, Yusuf C. Kaplan, Gideon Koren

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Vulvovaginal candidiasis (VVC) affects up to 75% of women at least once during their lifetime, mostly during the reproductive age, and recurrence rate is about 50%. Because half of all pregnancies are unplanned and pregnant women have an increased risk of VVC recurrence, the likelihood of inadvertently being exposed to fluconazole in pregnancy is increased. Thus, we aimed to examine the risk of congenital malformations in the offspring of women exposed to fluconazole in the first trimester of pregnancy. The rate for overall malformations was 1.10 (95% CI 0.98-1.25), for heart defect was 1.29 (95% CI 1.05-1.58), for craniofacial defects was 1.25 (95% CI 0.88-1.77), and for limb/musculoskeletal defects was 0.82 (95% CI 0.59-1.13). In conclusion, the use of fluconazole in the first trimester does not appear to increase the overall risk for congennital malformations. More studies are needed to address the potential increased rate of heart defects.

Original languageEnglish
Pages (from-to)78-82
Number of pages5
JournalReproductive Toxicology
Volume52
DOIs
StatePublished - 1 Apr 2015
Externally publishedYes

Keywords

  • Cardiovascular defects
  • Fluconazole
  • Infants
  • Pregnancy
  • Teratogenicity
  • Vulvovaginal candidiasis

Fingerprint

Dive into the research topics of 'Exposure to fluconazole and risk of congenital malformations in the offspring: A systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this