Abstract
Anticancer drugs connected to fluorescein based chemosensors by different biodegradable linkers were investigated for fluorescent monitoring in drug delivery models. The drug release triggered by chemo- and bio-hydrolytic environments was visualized on the basis of “switch on” fluorescence of the fluorophore moiety of fluorescein-drug conjugates. The conjugation of free phenolic hydroxyl of fluorescein chemosensor to the hydroxyl group of the drugs was employed by biodegradable oxy- and amino acrylate linkers. The chemosensor also possesses a free carboxylic group for potential conjugation to a specific carrier for targeted drug delivery applications. Fluorescent monitoring of drug release, quantum yield and other spectroscopic characteristics of our novel fluorescein-drug conjugates were measured and discussed. The work offers a versatile fluorophore platform for the fluorescent observation of drug delivery.
| Original language | English |
|---|---|
| Pages (from-to) | 460-472 |
| Number of pages | 13 |
| Journal | Dyes and Pigments |
| Volume | 139 |
| DOIs | |
| State | Published - 1 Apr 2017 |
Keywords
- Anticancer
- Chemosensing
- Drug conjugates
- Drug delivery monitoring
- Fluorescein
- Fluorescence
- TDD